Colon cancer associated genes exhibit signatures of positive selection at functionally significant positions

BMC Evolutionary Biology

Research Article

Thomas A Walsh¹  Mary J O’Connell¹  Andrew Webb¹  Claire C Morgan¹  Mark Lynch²  Kabita Shakya³  Heather J Ruskin⁴  Christine E Loscher⁵ 

[1] Bioinformatics and Molecular Evolution Group, School of Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland;Centre for Scientific Computing & Complex Systems Modelling (SCI-SYM), Dublin City University, Glasnevin, Dublin 9, Ireland;Bioinformatics and Molecular Evolution Group, School of Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland;Centre for Scientific Computing & Complex Systems Modelling (SCI-SYM), Dublin City University, Glasnevin, Dublin 9, Ireland;Immunomodulatory Research Group, School of Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland;Bioinformatics and Molecular Evolution Group, School of Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland;Centre for Scientific Computing & Complex Systems Modelling (SCI-SYM), Dublin City University, Glasnevin, Dublin 9, Ireland;School of Computing, Dublin City University, Glasnevin, Dublin 9, Ireland;Centre for Scientific Computing & Complex Systems Modelling (SCI-SYM), Dublin City University, Glasnevin, Dublin 9, Ireland;School of Computing, Dublin City University, Glasnevin, Dublin 9, Ireland;Immunomodulatory Research Group, School of Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland;

关键词: Positive selection;    Colon cancer;    Adaptive evolution;    Protein functional shift;    Selective pressure;    Evolutionary medicine;   

DOI  :  10.1186/1471-2148-12-114

 received in 2012-02-01, accepted in 2012-06-22,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundCancer, much like most human disease, is routinely studied by utilizing model organisms. Of these model organisms, mice are often dominant. However, our assumptions of functional equivalence fail to consider the opportunity for divergence conferred by ~180 Million Years (MY) of independent evolution between these species. For a given set of human disease related genes, it is therefore important to determine if functional equivalency has been retained between species. In this study we test the hypothesis that cancer associated genes have different patterns of substitution akin to adaptive evolution in different mammal lineages.ResultsOur analysis of the current literature and colon cancer databases identified 22 genes exhibiting colon cancer associated germline mutations. We identified orthologs for these 22 genes across a set of high coverage (>6X) vertebrate genomes. Analysis of these orthologous datasets revealed significant levels of positive selection. Evidence of lineage-specific positive selection was identified in 14 genes in both ancestral and extant lineages. Lineage-specific positive selection was detected in the ancestral Euarchontoglires and Hominidae lineages for STK11, in the ancestral primate lineage for CDH1, in the ancestral Murinae lineage for both SDHC and MSH6 genes and the ancestral Muridae lineage for TSC1.ConclusionIdentifying positive selection in the Primate, Hominidae, Muridae and Murinae lineages suggests an ancestral functional shift in these genes between the rodent and primate lineages. Analyses such as this, combining evolutionary theory and predictions - along with medically relevant data, can thus provide us with important clues for modeling human diseases.

【 授权许可】

Unknown   
© Morgan et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.