Dietary supplementation with rice bran fermented with Lentinus edodesincreases interferon-γ activity without causing adverse effects: a randomized, double-blind, placebo-controlled, parallel-group study

Nutrition Journal

Research

Doo-Jin Paik¹  Ji-young Choi²  Yongsoon Park²  Dae Young Kwon³ 

[1] Department of Anatomy and Cell Biology, College of Medicine, Hanyang University, Seoul, South Korea;Department of Food and Nutrition, Hanyang University, Seoul, South Korea;Emerging Innovative Technology Research Division, Korean Food Research Institutes, Sungnam, South Korea;

关键词: Cytokines;    Fermented rice bran;    Immune response;    Natural killer cell;    Randomized clinical study;   

DOI  :  10.1186/1475-2891-13-35

 received in 2014-01-15, accepted in 2014-04-14,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundThe purpose of this study was to investigate the hypothesis that dietary supplementation with rice bran fermented with Lentinus edodes (rice bran exo-biopolymer, RBEP), a substance known to contain arabinoxylan, enhances natural killer (NK) cell activity and modulates cytokine production in healthy adults.MethodsThis study was designed in a randomized, double-blind, placebo-controlled, and parallel-group format. Eighty healthy participants with white blood cell counts of 4,000-8,000 cells/μL were randomly assigned to take six capsules per day of either 3 g RBEP or 3 g placebo for 8 weeks. Three participants in the placebo group were excluded after initiation of the protocol; no severe adverse effects from RBEP supplementation were reported. NK cell activity of peripheral blood mononuclear cells was measured using nonradioactive cytotoxicity assay kits and serum cytokine concentrations included interferon (IFN)-γ, tumor necrosis factor (TNF)-α, interleukin (IL)-2, IL-4, IL-10, and IL-12 were measured by Bio-Plex cytokine assay kit. This study was registered with the Clinical Research Information Service (KCT0000536).ResultsSupplementation of RBEP significantly increased IFN-γ production compared with the placebo group (P = 0.012). However, RBEP supplementation did not affect either NK cell activity or cytokine levels, including IL-2, IL-4, IL-10, IL-12, and TNF-α, compared with the placebo group.ConclusionsThe data obtained in this study indicate that RBEP supplementation increases IFN-γ secretion without causing significant adverse effects, and thus may be beneficial to healthy individuals. This new rice bran-derived product may therefore be potentially useful to include in the formulation of solid and liquid foods designed for treatment and prevention of pathological states associated with defective immune responses.

【 授权许可】

Unknown   
© Choi et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.