Establishing a China malaria diagnosis reference laboratory network for malaria elimination

Malaria Journal

Research

Fang Huang¹  Shui-sen Zhou¹  Hui-hui Xiao¹  He Yan¹  Jian-hai Yin¹  Mei Li¹  Zhi-gui Xia¹ 

[1] National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai 200025, Shanghai, People’s Republic of China;WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis, Key Laboratory of Parasite and Vector Biology, Ministry of Health, 200025, Shanghai, People’s Republic of China;

关键词: Malaria diagnosis;    Quality assurance;    Reference laboratory;    Malaria elimination;    China;   

DOI  :  10.1186/s12936-015-0556-z

 received in 2014-12-08, accepted in 2015-01-09,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundIn China, the prevalence of malaria has reduced dramatically due to the elimination programme. The continued success of the programme will depend upon the accurate diagnosis of the disease in the laboratory. The basic requirements for this are a reliable malaria diagnosis laboratory network and quality management system to support case verification and source tracking.MethodsThe baseline information of provincial malaria laboratories in the China malaria diagnosis reference laboratory network was collected and analysed, and a quality-assurance activity was carried out to assess their accuracies in malaria diagnosis by microscopy using WHO standards and PCR.ResultsBy the end of 2013, nineteen of 24 provincial laboratories have been included in the network. In the study, a total of 168 staff were registered and there was no bias in their age, gender, education level, and position. Generally Plasmodium species were identified with great accuracy by microscopy and PCR. However, Plasmodium ovale was likely to be misdiagnosed as Plasmodium vivax by microscopy.ConclusionsChina has established a laboratory network for primary malaria diagnosis which will cover a larger area. Currently, Plasmodium species can be identified fairly accurately by microscopy and PCR. However, laboratory staff need additional trainings on accurate identification of P. ovale microscopically and good performance of PCR operations.

【 授权许可】

Unknown   
© Yin et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.