High or low calcium intake increases cardiovascular disease risks in older patients with type 2 diabetes

Cardiovascular Diabetology

Original Investigation

Jui-Hua Huang¹  Yu-Chen Chang²  Leih-Ching Tsai³  Fu-Chou Cheng⁴ 

[1] Department of Community Health, Chia-Yi Christian Hospital, Chia-Yi, Taiwan;Department of Community Health, Chia-Yi Christian Hospital, Chia-Yi, Taiwan;Department of Geriatric Medicine, Chia-Yi Christian Hospital, Chia-Yi, Taiwan;Division of Endocrine and Metabolism, Department of Internal Medicine, Erlin-Branch, Changhua Christian Hospital, Changhua, Taiwan;Stem Cell Center, Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan;

关键词: Calcium;    Magnesium;    Inflammation;    Cardiovascular disease risk;    Older patients with diabetes;   

DOI  :  10.1186/s12933-014-0120-0

 received in 2014-05-14, accepted in 2014-07-23,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundWe investigated the effects of dietary calcium (Ca) and magnesium (Mg) intakes on cardiovascular disease risks in older patients with diabetes.MethodsIn this cross-sectional study, 197 patients with type 2 diabetes aged 65 years and above were recruited. The 24-h dietary recalls and 1-week self-reported typical dietary intake patterns were collected. The Ca and Mg intakes of <67% of the recommended dietary allowance (RDA), 67%–100% of RDA, and >100% of RDA were defined as low, moderate, and high Ca and Mg intakes, respectively. Anthropometric measurements were determined and biochemical analysis of blood and urine was performed.ResultsOur data indicated that 60.9% and 87.3% of our patients were Ca and Mg intakes below RDA, respectively. Patients whose Ca intake was high or low (81.2%) had significantly higher C-reactive protein (CRP) than those whose Ca intake was moderate (p = 0.043). Furthermore, patients whose Mg intake was low (87.3%) had significantly higher CRP than that of those who took adequate Mg (p = 0.025). The dietary Ca:Mg intake ratios were highly correlated with CRP, platelet counts, and red blood cell distribution (p < 0.05). A dietary Ca:Mg intake ratio of 2.0–2.5 was significantly correlated to lower CRP levels (p = 0.013).ConclusionsHigh or low calcium intake increases cardiovascular disease risks. We suggest that “moderate” intake of 402–600 mg Ca/day (approximately 67%–100% of Taiwan RDA for Ca) and adequate Mg intake (or meeting RDA for Mg) with Ca:Mg intake ratio of 2.0–2.5 are important for reducing cardiovascular disease risks in older patients with diabetes.

【 授权许可】

Unknown   
© Huang et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.