Analytical method to measure three-dimensional strain patterns in the left ventricle from single slice displacement data

Journal of Cardiovascular Magnetic Resonance

Research

Nikoo R Saber¹  Morteza Gharib¹  Daniel B Ennis²  J Paul Finn²  Abbas Nasiraei Moghaddam³  Han Wen⁴ 

[1] Bioengineering Option, California Institute of Technology, Pasadena, CA, USA;Department of Radiological Sciences, Diagnostic Cardiovascular Imaging Section, David Geffen School of Medicine, University of California, Los Angeles, CA, USA;Department of Radiological Sciences, Diagnostic Cardiovascular Imaging Section, David Geffen School of Medicine, University of California, Los Angeles, CA, USA;Bioengineering Option, California Institute of Technology, Pasadena, CA, USA;National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA;

关键词: Cardiovascular Magnetic Resonance;    Late Gadolinium Enhancement;    Strain Calculation;    Theory Section;    Deformation Gradient Tensor;   

DOI  :  10.1186/1532-429X-12-33

 received in 2010-01-12, accepted in 2010-06-01,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundDisplacement encoded Cardiovascular MR (CMR) can provide high spatial resolution measurements of three-dimensional (3D) Lagrangian displacement. Spatial gradients of the Lagrangian displacement field are used to measure regional myocardial strain. In general, adjacent parallel slices are needed in order to calculate the spatial gradient in the through-slice direction. This necessitates the acquisition of additional data and prolongs the scan time. The goal of this study is to define an analytic solution that supports the reconstruction of the out-of-plane components of the Lagrangian strain tensor in addition to the in-plane components from a single-slice displacement CMR dataset with high spatio-temporal resolution. The technique assumes incompressibility of the myocardium as a physical constraint.ResultsThe feasibility of the method is demonstrated in a healthy human subject and the results are compared to those of other studies. The proposed method was validated with simulated data and strain estimates from experimentally measured DENSE data, which were compared to the strain calculation from a conventional two-slice acquisition.ConclusionThis analytical method reduces the need to acquire data from adjacent slices when calculating regional Lagrangian strains and can effectively reduce the long scan time by a factor of two.

【 授权许可】

Unknown   
© Moghaddam et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.