Comparison of ELF, FibroTest and FibroScan for the non-invasive assessment of liver fibrosis

BMC Gastroenterology

Research Article

William Rosenberg¹  Mireen Friedrich-Rust²  Julie Parkes³ 

[1] Centre for Hepatology, Division of Medicine, University College London, London, UK;Department of Internal Medicine 1, J.W. Goethe-University Hospital, Frankfurt, Germany;Department of Public Health and Medical Statistics, University of Southampton, Southampton, UK;

关键词: Hyaluronic Acid;    Liver Biopsy;    Liver Fibrosis;    Primary Biliary Cirrhosis;    Fibrosis Stage;   

DOI  :  10.1186/1471-230X-10-103

 received in 2010-03-02, accepted in 2010-09-09,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundFibroTest (FT) is the most frequently used serum fibrosis marker and consists of an algorithm of five fibrosis markers (alfa2-macroglobulin, apolipoproteinA1, haptoglobin, GGT, bilirubin). The Enhanced Liver Fibrosis (ELF) test consists of an algorithm of three fibrosis markers (hyaluronic acid, amino-terminal propeptide-of-type-III-collagen, tissue-inhibitor of matrix-metaloproteinase-1). While a systematic review has shown comparable results for both individual markers, there has been no direct comparison of both markers.MethodsIn the present study, the ELF-test was analyzed retrospectively in patients with chronic liver disease, who received a liver biopsy, transient elastography (TE) and the FibroTest using histology as the reference method. Histology was classified according to METAVIR and the Ludwig's classification (F0-F4) for patients with chronic hepatitis C and B virus (HCV, HBV) infection and primary biliary cirrhosis (PBC), respectively.ResultsSeventy-four patients were analysed: 36 with HCV, 10 with HBV, and 28 with PBC. The accuracy (AUROC) for the diagnosis of significant fibrosis (F≥2) for ELF and FibroTest was 0.78 (95%CI:0.67-0.89) and 0.69 (95%-CI:0.57-0.82), respectively (difference not statistically significant, n.s.). The AUROC for the diagnosis of liver cirrhosis was 0.92 (95%CI:0.83-1,00), and 0.91 (95%CI:0.83-0.99), respectively (n.s.). For 66 patients with reliable TE measurements the AUROC for the diagnosis of significant fibrosis (cirrhosis) for TE, ELF and FT were 0.80 (0.94), 0.76 (0.92), and 0.67 (0.91), respectively (n.s.).ConclusionFibroTest and ELF can be performed with comparable diagnostic accuracy for the non-invasive staging of liver fibrosis. Serum tests are informative in a higher proportion of patients than transient elastography.

【 授权许可】

Unknown   
© Friedrich-Rust et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.