Cancer stem cell niche models and contribution by mesenchymal stroma/stem cells

Molecular Cancer

Review

Juliane von der Ohe¹  Ralf Hass¹  Catharina Melzer¹  Hendrik Lehnert²  Hendrik Ungefroren³ 

[1] Biochemistry and Tumor Biology Lab, Department of Obstetrics and Gynecology, Hannover Medical School, Medical University Hannover, Carl-Neuberg-Str. 1, D – 30625, Hannover, Germany;First Department of Medicine, University Hospital Schleswig-Holstein (UKSH), Campus Lübeck, Lübeck, Germany;First Department of Medicine, University Hospital Schleswig-Holstein (UKSH), Campus Lübeck, Lübeck, Germany;Department of General, Visceral-, Thoracic-Transplantation- and Pediatric Surgery, UKSH, Campus Kiel, Kiel, Germany;

关键词: Cancer stem cells;    Tumor cell interaction;    Tumor microenvironment;    MSC;    Retrodifferentiation;   

DOI  :  10.1186/s12943-017-0595-x

 received in 2016-10-24, accepted in 2017-01-18,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThe initiation and progression of malignant tumors is driven by distinct subsets of tumor-initiating or cancer stem-like cells (CSCs) which develop therapy/apoptosis resistance and self-renewal capacity. In order to be able to eradicate these CSCs with novel classes of anti-cancer therapeutics, a better understanding of their biology and clinically-relevant traits is mandatory.Main bodySeveral requirements and functions of a CSC niche physiology are combined with current concepts for CSC generation such as development in a hierarchical tumor model, by stochastic processes, or via a retrodifferentiation program. Moreover, progressive adaptation of endothelial cells and recruited immune and stromal cells to the tumor site substantially contribute to generate a tumor growth-permissive environment resembling a CSC niche. Particular emphasis is put on the pivotal role of multipotent mesenchymal stroma/stem cells (MSCs) in supporting CSC development by various kinds of interaction and cell fusion to form hybrid tumor cells.ConclusionA better knowledge of CSC niche physiology may increase the chances that cancer stemness-depleting interventions ultimately result in arrest of tumor growth and metastasis.

【 授权许可】

CC BY   
© The Author(s). 2017