期刊论文详细信息
Malaria Journal
Sample size and power calculations for detecting changes in malaria transmission using antibody seroconversion rate
Methodology
Carlos Daniel Paulino1  Chris Drakeley2  Nuno Sepúlveda3 
[1] Center of Statistics and Applications of University of Lisbon, Faculdade de Ciências da Universidade de Lisboa, Bloco C6-Piso 4, 1749-1016, Lisbon, Portugal;Instituto Superior Técnico, Universidade Técnica de Lisboa, Avenida Rovisco Pais, 1049-001, Lisbonn, Portugal;London School of Hygiene and Tropical Medicine, Keppel Street, WC1E 7HT, London, UK;London School of Hygiene and Tropical Medicine, Keppel Street, WC1E 7HT, London, UK;Center of Statistics and Applications of University of Lisbon, Faculdade de Ciências da Universidade de Lisboa, Bloco C6-Piso 4, 1749-1016, Lisbon, Portugal;
关键词: Intervention;    Malaria transmission;    Bias;    Precision;    Sample size;   
DOI  :  10.1186/s12936-015-1050-3
 received in 2015-06-20, accepted in 2015-12-12,  发布年份 2015
来源: Springer
PDF
【 摘 要 】

BackgroundSeveral studies have highlighted the use of serological data in detecting a reduction in malaria transmission intensity. These studies have typically used serology as an adjunct measure and no formal examination of sample size calculations for this approach has been conducted.MethodsA sample size calculator is proposed for cross-sectional surveys using data simulation from a reverse catalytic model assuming a reduction in seroconversion rate (SCR) at a given change point before sampling. This calculator is based on logistic approximations for the underlying power curves to detect a reduction in SCR in relation to the hypothesis of a stable SCR for the same data. Sample sizes are illustrated for a hypothetical cross-sectional survey from an African population assuming a known or unknown change point.ResultsOverall, data simulation demonstrates that power is strongly affected by assuming a known or unknown change point. Small sample sizes are sufficient to detect strong reductions in SCR, but invariantly lead to poor precision of estimates for current SCR. In this situation, sample size is better determined by controlling the precision of SCR estimates. Conversely larger sample sizes are required for detecting more subtle reductions in malaria transmission but those invariantly increase precision whilst reducing putative estimation bias.ConclusionsThe proposed sample size calculator, although based on data simulation, shows promise of being easily applicable to a range of populations and survey types. Since the change point is a major source of uncertainty, obtaining or assuming prior information about this parameter might reduce both the sample size and the chance of generating biased SCR estimates.

【 授权许可】

CC BY   
© Sepúlveda et al. 2015

【 预 览 】
附件列表
Files Size Format View
RO202311101047662ZK.pdf 1328KB PDF download
Fig. 1 258KB Image download
Fig. 5 993KB Image download
42004_2023_1031_Article_IEq16.gif 1KB Image download
Scheme 1 2400KB Image download
Fig. 7 5148KB Image download
12951_2017_255_Article_IEq56.gif 1KB Image download
12936_2017_2118_Article_IEq1.gif 2KB Image download
12936_2015_1050_Article_IEq030.gif 1KB Image download
MediaObjects/12888_2023_5250_MOESM1_ESM.doc 111KB Other download
Fig. 3 390KB Image download
Fig. 2 314KB Image download
Fig. 4 987KB Image download
Fig. 2 550KB Image download
Fig. 6 571KB Image download
12936_2023_4742_Article_IEq70.gif 1KB Image download
MediaObjects/40798_2023_638_MOESM1_ESM.docx 53KB Other download
Fig. 11 7606KB Image download
Fig. 3 198KB Image download
【 图 表 】

Fig. 3

Fig. 11

12936_2023_4742_Article_IEq70.gif

Fig. 6

Fig. 2

Fig. 4

Fig. 2

Fig. 3

12936_2015_1050_Article_IEq030.gif

12936_2017_2118_Article_IEq1.gif

12951_2017_255_Article_IEq56.gif

Fig. 7

Scheme 1

42004_2023_1031_Article_IEq16.gif

Fig. 5

Fig. 1

【 参考文献 】
  • [1]
  • [2]
  • [3]
  • [4]
  • [5]
  • [6]
  • [7]
  • [8]
  • [9]
  • [10]
  • [11]
  • [12]
  • [13]
  • [14]
  • [15]
  • [16]
  • [17]
  • [18]
  • [19]
  • [20]
  • [21]
  • [22]
  • [23]
  • [24]
  • [25]
  • [26]
  • [27]
  • [28]
  • [29]
  • [30]
  • [31]
  • [32]
  • [33]
  • [34]
  • [35]
  • [36]
  • [37]
  • [38]
  • [39]
  • [40]
  文献评价指标  
  下载次数:28次 浏览次数:1次