Prevalence of Plasmodium spp. in illegal gold miners in French Guiana in 2015: a hidden but critical malaria reservoir

Malaria Journal

Research

Paul Brousse¹  Magalie Demar²  Stephen Vreden³  Felix Djossou⁴  Louise Mutricy⁵  Florine Corlin⁵  Maylis Douine⁶  Antoine Adenis⁶  Mathieu Nacher⁶  Lise Musset⁷  Stéphane Pelleau⁷  Jérémie Pasquier⁸  Helene Hiwat⁹  Frédérique Perotti^1,10 

[1] Centres Délocalisés de Prévention et de Soins, Cayenne Hospital, Cayenne, France;Equipe EA 3593, Ecosystèmes Amazoniens et Pathologie Tropicale, Université de Guyane, Cayenne, France;Laboratoire hospitalo-universitaire de Parasitologie-Mycologie, Cayenne Hospital, Cayenne, France;Foundation of Scientific Research Suriname (SWOS), Paramaribo, Suriname;Infectious and Tropical Diseases Department, Cayenne Hospital, Cayenne, France;Inserm CIC 1424, Centre d’Investigation Clinique Antilles Guyane, Centre Hospitalier de Cayenne, BP 6006, Rue des Flamboyant, 97306, Cayenne Cedex, France;Inserm CIC 1424, Centre d’Investigation Clinique Antilles Guyane, Centre Hospitalier de Cayenne, BP 6006, Rue des Flamboyant, 97306, Cayenne Cedex, France;Equipe EA 3593, Ecosystèmes Amazoniens et Pathologie Tropicale, Université de Guyane, Cayenne, France;Laboratoire de Parasitologie, WHO Collaborating Centre for Surveillance of Anti-Malarial Drug Resistance, Centre National de Référence du paludisme, Institut Pasteur de la Guyane, Cayenne, France;Laboratoire hospitalo-universitaire de Parasitologie-Mycologie, Cayenne Hospital, Cayenne, France;Malaria Programme, Ministry of Health, Paramaribo, Suriname;Pharmacy, Centre Hospitalier de l’Ouest Guyanais, Saint Laurent du Maroni, France;

关键词: Malaria;    Illegal gold mining;    French Guiana;    Guiana Shield;    Malaria reservoir;   

DOI  :  10.1186/s12936-016-1367-6

 received in 2015-12-17, accepted in 2016-06-02,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundMalaria is endemic in French Guiana, an overseas territory of France on the Guiana Shield. Since 2005, notified malaria cases are decreasing. However, new data show that malaria affects many Brazilian gold miners working illegally in French Guiana, the majority of whom are not counted in official data. In addition, one major concern is the usual practice of improper self-treatment in this mining population, raising fear of the development of anti-malarial resistance. This prospective study, conducted in 2015, aimed to estimate the prevalence of Plasmodium spp. in illegal gold miners working in French Guiana.MethodsThe recruitment of gold miners was carried out in resting sites along the French Guiana-Suriname border, where they go for supplies, medical care or leisure. After recording agreement, three malaria diagnostic methods were performed: rapid diagnostic test, microscopy and PCR.ResultsAmong 421 persons recruited in the study, malaria prevalence, detected by nested-PCR, was 22.3 % (CI [18.3–26.3], n = 94/421) of which 84 % were asymptomatic.ConclusionsThis significant malaria reservoir in a mobile and illegal population with difficult access to a health care system raises the threat of artemisinin resistance and puts the population of the Guiana Shield at risk of new transmission foci while countries of the region aim at malaria elimination. Even though French legislation may hamper dealing with this population, France must face the reality of malaria in illegal gold miners in order to meet its commitment to malaria elimination.

【 授权许可】

CC BY   
© The Author(s) 2016