Anthropometric, biochemical and clinical assessment of malnutrition in Malaysian patients with advanced cirrhosis

Nutrition Journal

Research

Siti Hawa Mohd-Taib¹  Khean-Lee Goh²  Sanjiv Mahadeva²  Mei-Ling S Tai²  Sanjay Rampal³ 

[1] Department of Dietitics, University Malaya Medical Centre, Jalan University, 59100, Kuala Lumpur, Malaysia;Department of Medicine, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia;Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia;

关键词: Cirrhotic Patient;    Alcoholic Liver Disease;    Nutritional Assessment;    Handgrip Strength;    Alcoholic Cirrhosis;   

DOI  :  10.1186/1475-2891-9-27

 received in 2009-12-27, accepted in 2010-06-24,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundThere is limited data on the nutritional status of Asian patients with various aetiologies of cirrhosis. This study aimed to determine the prevalence of malnutrition and to compare nutritional differences between various aetiologies.MethodologyA cross-sectional study of adult patients with decompensated cirrhosis was conducted. Nutritional status was assessed using standard anthropometry, serum visceral proteins and subjective global assessment (SGA).ResultsThirty six patients (mean age 59.8 ± 12.8 years; 66.7% males; 41.6% viral hepatitis; Child-Pugh C 55.6%) with decompensated cirrhosis were recruited. Malnutrition was prevalent in 18 (50%) patients and the mean caloric intake was low at 15.2 kcal/kg/day. SGA grade C, as compared to SGA grade B, demonstrated significantly lower anthropometric values in males (BMI 18.1 ± 1.6 vs 26.3 ± 3.5 kg/m2, p < 0.0001; MAMC 19.4 ± 1.5 vs 24.5 ± 3.6 cm, p = 0.002) and females (BMI 19.4 ± 2.7 vs 28.9 ± 4.3, p = 0.001; MAMC 18.0 ± 0.9 vs 28.1 ± 3.6, p < 0.0001), but not with visceral proteins. The SGA demonstrated a trend towards more malnutrition in Child-Pugh C compared to Child-Pugh B liver cirrhosis (40% grade C vs 25% grade C, p = 0.48). Alcoholic cirrhosis had a higher proportion of SGA grade C (41.7%) compared to viral (26.7%) and cryptogenic (28.6%) cirrhosis, but this was not statistically significant.ConclusionSignificant malnutrition in Malaysian patients with advanced cirrhosis is common. Alcoholic cirrhosis may have more malnutrition compared to other aetiologies of cirrhosis.

【 授权许可】

Unknown   
© Tai et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.