Establishing a composite endpoint for measuring the effectiveness of geriatric interventions based on older persons’ and informal caregivers’ preference weights: a vignette study

BMC Geriatrics

Research Article

Rogier ART Donders¹  Han Boter²  René JF Melis³  Marcel GM Olde Rikkert³  Peter Makai³  Cynthia S Hofman⁴  Anton JM de Craen⁵  Bianca M Buurman⁶ 

[1] Department for Health Evidence (HP133), Radboud University Medical Center, PO Box 9101, 6500, Nijmegen, HB, The Netherlands;Department of Epidemiology (FA41), University of Groningen, University Medical Centre, PO Box 30001, 9700 RB, Groningen, Groningen, The Netherlands;Department of Geriatric Medicine (HP 925), Radboud University Medical Center, PO Box 9101, 6500, Nijmegen, HB, The Netherlands;Department of Geriatric Medicine (HP 925), Radboud University Medical Center, PO Box 9101, 6500, Nijmegen, HB, The Netherlands;Department for Health Evidence (HP133), Radboud University Medical Center, PO Box 9101, 6500, Nijmegen, HB, The Netherlands;Department of Gerontology and Geriatrics (C2-R), Leiden University Medical Centre, PO Box 9600, 2300 RC, Leiden, The Netherlands;Department of Internal Medicine, Section of Geriatric Medicine (F4-108), Academic Medical Center, PO Box 22660, 1100 DD, Amsterdam, The Netherlands;

关键词: Composite endpoint;    Preference-weighted;    Elderly persons;    Informal caregivers;    Effectiveness;    Geriatric interventions;   

DOI  :  10.1186/1471-2318-14-51

 received in 2013-08-26, accepted in 2014-04-07,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundThe Older Persons and Informal Caregivers Survey Minimal Dataset’s (TOPICS-MDS) questionnaire which measures relevant outcomes for elderly people was successfully incorporated into over 60 research projects of the Dutch National Care for the Elderly Programme. A composite endpoint (CEP) for this instrument would be helpful to compare effectiveness of the various intervention projects. Therefore, our aim is to establish a CEP for the TOPICS-MDS questionnaire, based on the preferences of elderly persons and informal caregivers.MethodsA vignette study was conducted with 200 persons (124 elderly and 76 informal caregivers) as raters. The vignettes described eight TOPICS-MDS outcomes of older persons (morbidity, functional limitations, emotional well-being, pain experience, cognitive functioning, social functioning, self-perceived health and self-perceived quality of life) and the raters assessed the general well-being (GWB) of these vignette cases on a numeric rating scale (0–10). Mixed linear regression analyses were used to derive the preference weights of the TOPICS-MDS outcomes (dependent variable: GWB scores; fixed factors: the eight outcomes; unstandardized coefficients: preference weights).ResultsThe mixed regression model that combined the eight outcomes showed that the weights varied from 0.01 for social functioning to 0.16 for self-perceived health. A model that included “informal caregiver” showed that the interactions between this variable and each of the eight outcomes were not significant (p > 0.05).ConclusionA preference-weighted CEP for TOPICS-MDS questionnaire was established based on the preferences of older persons and informal caregivers. With this CEP optimal comparing the effectiveness of interventions in older persons can be realized.

【 授权许可】

CC BY   
© Hofman et al.; licensee BioMed Central Ltd. 2014