Quantitative comparison of myocardial fiber structure between mice, rabbit, and sheep using diffusion tensor cardiovascular magnetic resonance

Journal of Cardiovascular Magnetic Resonance

Research

Yi Jiang¹  Lindsey J Healy²  Edward W Hsu² 

[1] Center for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina, USA;Department of Bioengineering, University of Utah, Salt Lake City, Utah, USA;

关键词: Diffusion Tensor Imaging;    Fiber Orientation;    Helix Angle;    Myocardial Fiber;    Myocardial Structure;   

DOI  :  10.1186/1532-429X-13-74

 received in 2011-05-04, accepted in 2011-11-25,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundAccurate interpretations of cardiac functions require precise structural models of the myocardium, but the latter is not available always and for all species. Although scaling or substitution of myocardial fiber information from alternate species has been used in cardiac functional modeling, the validity of such practice has not been tested.MethodsFixed mouse (n = 10), rabbit (n = 6), and sheep (n = 5) hearts underwent diffusion tensor imaging (DTI). The myocardial structures in terms of the left ventricular fiber orientation helix angle index were quantitatively compared between the mouse rabbit and sheep hearts.ResultsThe results show that significant fiber structural differences exist between any two of the three species. Specifically, the subepicardial fiber orientation, and the transmural range and linearity of fiber helix angles are significantly different between the mouse and either rabbit or sheep. Additionally, a significant difference was found between the transmural helix angle range between the rabbit and sheep. Across different circumferential regions of the heart, the fiber orientation was not found to be significantly different.ConclusionsThe current study indicates that myocardial structural differences exist between different size hearts. An immediate implication of the present findings for myocardial structural or functional modeling studies is that caution must be exercised when extrapolating myocardial structures from one species to another.

【 授权许可】

CC BY   
© Healy et al; licensee BioMed Central Ltd. 2011