Gender differences in the prevalence of congenital heart disease in Down’s syndrome: a brief meta-analysis

BMC Medical Genetics

Research Article

Sandra da Silva Mattos¹  Tereza Cristina Pinheiro Diogenes¹  Felipe Alves Mourato²  José Luiz de Lima Filho³ 

[1] Círculo do Coração de Pernambuco, Recife, Pernambuco, Brazil;Universidade Federal de Pernambuco (UFPE), Recife, Pernambuco, Brazil;Círculo do Coração de Pernambuco, Recife, Pernambuco, Brazil;Universidade Federal de Pernambuco (UFPE), Recife, Pernambuco, Brazil;Unidade de Cardiologia Materno e Fetal (UCMF), Av. Governador Agamenon Magalhães, 4760, CEP 52010-902, Paissandu, PE, Brazil;Universidade Federal de Pernambuco (UFPE), Recife, Pernambuco, Brazil;

关键词: Down;    Gender;    Meta-analysis;    Systematic review;    Congenital heart disease;   

DOI  :  10.1186/s12881-017-0475-7

 received in 2017-06-13, accepted in 2017-10-03,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundDown’s syndrome (DS) affects one per 700 live births and congenital heart disease (CHD) occurs in 40–60% of these patients. Contributing factors to the association between DS and CHD are being unraveled. Gender could be one of them.MethodsWe performed a meta-analysis of CHD prevalence in DS, separated by gender. Three search engines were used and 578 articles were reviewed. Twelve articles were included.ResultsQuantitative analysis showed a higher prevalence of CHD, particularly atrioventricular septal defects (AVSD), in female patients. No differences were found in others forms of CHD.ConclusionCHD, particularly AVSD, are more common in the female gender of Down’s syndrome patients.

【 授权许可】

CC BY   
© The Author(s). 2017