Metabolic syndrome is independently associated with a mildly reduced estimated glomerular filtration rate: a cross-sectional study

BMC Nephrology

Research Article

Yao-Jun Ni¹  Xiao-Juan Wu²  Hai-Rong Hao²  Wei-Nan Yu²  Wen Hu³  Hong-Wen Zhou⁴ 

[1] Department of Cardiothoracic Surgery, Hospital Affiliated to Nanjing Medical University and Huai’an First People’s Hospital, 223001, Huai’an, China;Department of Endocrinology and Metabolism, Huai’an Hospital Affiliated to Xuzhou Medical University and Huai’an Second People’s Hospital, 223001, Huai’an, China;Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, 210029, Nanjing, Jiangsu, China;Department of Endocrinology and Metabolism, Huai’an Hospital Affiliated to Xuzhou Medical University and Huai’an Second People’s Hospital, 223001, Huai’an, China;Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, 210029, Nanjing, Jiangsu, China;Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, 210029, Nanjing, China;

关键词: Metabolic syndrome;    Mildly reduced eGFR;    Hyperfiltration;    Chinese;    Renal damage;   

DOI  :  10.1186/s12882-017-0597-3

 received in 2015-07-27, accepted in 2017-05-19,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundAssociation between metabolic syndrome (MS) and mildly reduced estimated glomerular filtration rates (eGFRs) remains unclear. Therefore, we aimed to evaluate the association between MS and a mildly reduced eGFR in Chinese adults.MethodsAnthropometric and biochemical examinations were performed in 2992 individuals. The eGFR was calculated from the creatinine level. MS was defined according to the Adult Treatment Panel III criteria as the presence of three or more risk factors. Mildly reduced eGFR was defined as a value between 60 and 90 mL/min/1.73 m2. Multiple linear regression and multiple logistic regression analysis were used to evaluate association between metabolic syndrome and estimate glomerular filtration rate.ResultsAfter adjusting for several potential confounders, the participants with MS showed a 1.29-fold increased odds ratio for a mildly reduced eGFR compared with those without MS. Additionally, the odds ratios (and 95% confidence intervals (CIs)) for mildly reduced eGFR in participants with elevated triglycerides (TG), decreased high-density lipoprotein (HDL), obesity and elevated fasting blood glucose (FPG) after multivariable adjustment were 1.25 (1.05–1.49), 1.23 (1.03–1.48), 1.22 (1.03–1.45) and 0.64 (0.52–0.78), respectively. The odds ratios (95% CIs) for hyperfiltration in participants with elevated FPG and HbA1c levels after multivariable adjustment were 1.53 (1.30–1.81) and 2.86 (2.00–4.09), respectively.ConclusionsMS is associated with an increased risk of a mildly reduced eGFR in the Chinese population, and several individual components of MS have different impacts on eGFR levels. MS had dual roles on renal damage.Trial registrationChiCTR-TRC-14005029. Registered 28 July 2014.

【 授权许可】

CC BY   
© The Author(s). 2017