Determination of the appropriate propofol infusion rate for outpatient upper gastrointestinal endoscopy-a randomized prospective study

BMC Gastroenterology

Research Article

Hongmei Zhou¹  Qinghe Zhou¹  Wangpin Xiao¹  Qiongzhen Li² 

[1]Department of Anesthesia, Second Hospital, Jiaxing Medical College, No. 1518, North Huancheng Road, Jianshe Street, Nanhu District, 314000, Jiaxing, Zhejiang, China

[2]Department of Anesthesia, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China

关键词: Propofol;    Outpatient;    Upper gastrointestinal endoscopy;    Sedation;    Complications;   

DOI  :  10.1186/s12876-016-0463-y

 received in 2015-12-01, accepted in 2016-04-09,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundPain and discomfort related to endoscopy sessions can be alleviated by sedation, which minimizes anxiety and allows safe examination. For outpatient endoscopy, reliable short-term sedation without secondary effects is required. This study aimed to assess the effects of intravenous propofol rates on sedation in outpatients undergoing upper gastrointestinal endoscopy.MethodsThis randomized prospective study evaluated 300 outpatients submitted to upper gastrointestinal endoscopy. Patients received propofol at 500, 1000 or 2000 ml/h. The primary outcome assessed was hypoxemia incidence. In addition, time to sedation and incidence of hypotension, deep sedation, extremity motor activity, cough, nausea, hiccough, and awareness were evaluated.ResultsRecovery time and incidence of hypoxemia, hypotension, and deep sedation were significantly increased in individuals treated at 2000 ml/h in comparison with values obtained for 500 and 1000 ml/h groups (P < 0.01). Compared with the 500 ml/h group, motor activity of the extremities, cough, nausea, hiccough, and awareness were significantly decreased and the mean scores for endoscopist’s and patients’ satisfaction were significantly increased in the 1000 and 2000 ml/h groups (P < 0.01).ConclusionPropofol infused at 1000 ml/h appeared to be the most suitable infusion rate for outpatient upper gastrointestinal endoscopy.Trial registrationRegistration number: ChiCTR-TRC-14004786; Registration date: 2014-06-04

【 授权许可】

CC BY   
© Li et al. 2016