An indoor air filtration study in homes of elderly: cardiovascular and respiratory effects of exposure to particulate matter

Environmental Health

Research

Michal Spilak¹  Marie Frederiksen¹  Barbara Kolarik¹  Lars Gunnarsen¹  Elvira Vaclavik Brauner¹  Torben Sigsgaard²  Gerd Sallsten³  Lars Barregard³  Bo Strandberg³  Dorina Gabriela Karottki⁴  Peter Møller⁴  Zorana Jovanovic Andersen⁴  Steffen Loft⁴ 

[1] Danish Building Research Institute, Department of Construction and Health, Aalborg University, Copenhagen, Denmark;Department of Environmental and Occupational Medicine, University of Aarhus, Aarhus, Denmark;Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital and Academy, Gothenburg, Sweden;Section of Environmental Health, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Farimagsgade, 5A K, DK-1014, Copenhagen, Denmark;

关键词: Endothelial function;    Indoor air pollution;    Intervention;    Inflammation;    Lung function;    Particles;   

DOI  :  10.1186/1476-069X-12-116

 received in 2013-12-12, accepted in 2013-12-19,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundExposure to particulate air pollution increases respiratory and cardiovascular morbidity and mortality, especially in elderly, possibly through inflammation and vascular dysfunction.MethodsWe examined potential beneficial effects of indoor air filtration in the homes of elderly, including people taking vasoactive drugs.Forty-eight nonsmoking subjects (51 to 81 years) in 27 homes were included in this randomized, double-blind, crossover intervention study with consecutive two-week periods with or without the inclusion of a high-efficiency particle air filter in re-circulating custom built units in their living room and bedroom. We measured blood pressure, microvascular and lung function and collected blood samples for hematological, inflammation, monocyte surface and lung cell damage markers before and at day 2, 7 and 14 during each exposure scenario.ResultsThe particle filters reduced the median concentration of PM2.5 from approximately 8 to 4 μg/m3 and the particle number concentration from 7669 to 5352 particles/cm3. No statistically significant effects of filtration as category were observed on microvascular and lung function or the biomarkers of systemic inflammation among all subjects, or in the subgroups taking (n = 11) or not taking vasoactive drugs (n = 37). However, the filtration efficacy was variable and microvascular function was within 2 days significantly increased with the actual PM2.5 decrease in the bedroom, especially among 25 subjects not taking any drugs.ConclusionSubstantial exposure contrasts in the bedroom and no confounding by drugs appear required for improved microvascular function by air filtration, whereas no other beneficial effect was found in this elderly population.

【 授权许可】

Unknown   
© Karottki et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.