Effect of calcium phosphate and vitamin D3supplementation on bone remodelling and metabolism of calcium, phosphorus, magnesium and iron

Nutrition Journal

Research

Ulrike Trautvetter¹  Gerhard Jahreis¹  Nadja Neef¹  Michael Kiehntopf²  Jürgen Kratzsch³  Matthias Leiterer⁴ 

[1] Department of Nutritional Physiology, Institute of Nutrition, Friedrich Schiller University of Jena, Dornburger Str, 24, D-07743, Jena, Germany;Institute of Clinical Chemistry and Laboratory Medicine, Friedrich Schiller University Jena, Erlanger Allee 101, D-07747, Jena, Germany;Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostic, University Leipzig, Liebigstr. 27, D-04103, Leipzig, Germany;Thuringian State Institute of Agriculture, Naumburger Str. 98, D-07743, Jena, Germany;

关键词: Vitamin D;    Calcium;    Phosphorus;    Magnesium;    Iron;    Human study;    Bone remodelling;   

DOI  :  10.1186/1475-2891-13-6

 received in 2013-07-16, accepted in 2014-01-08,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundThe aim of the present study was to determine the effect of calcium phosphate and/or vitamin D3 on bone and mineral metabolism.MethodsSixty omnivorous healthy subjects participated in the double-blind, placebo-controlled parallel designed study. Supplements were tricalcium phosphate (CaP) and cholecalciferol (vitamin D3). At the beginning of the study (baseline), all subjects documented their normal nutritional habits in a dietary record for three successive days. After baseline, subjects were allocated to three intervention groups: CaP (additional 1 g calcium/d), vitamin D3 (additional 10 μg/d) and CaP + vitamin D3. In the first two weeks, all groups consumed placebo bread, and afterwards, for eight weeks, the test bread according to the intervention group. In the last week of each study period (baseline, placebo, after four and eight weeks of intervention), a faecal (three days) and a urine (24 h) collection and a fasting blood sampling took place. Calcium, phosphorus, magnesium and iron were determined in faeces, urine and blood. Bone formation and resorption markers were analysed in blood and urine.ResultsAfter four and eight weeks, CaP and CaP + vitamin D3 supplementations increased faecal excretion of calcium and phosphorus significantly compared to placebo. Due to the vitamin D3 supplementations (vitamin D3, CaP + vitamin D3), the plasma 25-(OH)D concentration significantly increased after eight weeks compared to placebo. The additional application of CaP led to a significant increase of the 25-(OH)D concentration already after four weeks. Bone resorption and bone formation markers were not influenced by any intervention.ConclusionsSupplementation with daily 10 μg vitamin D3 significantly increases plasma 25-(OH)D concentration. The combination with daily 1 g calcium (as CaP) has a further increasing effect on the 25-(OH)D concentration. Both CaP alone and in combination with vitamin D3 have no beneficial effect on bone remodelling markers and on the metabolism of calcium, phosphorus, magnesium and iron.Trial registrationNCT01297023

【 授权许可】

Unknown   
© Trautvetter et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.