Membranous expression of Her3 is associated with a decreased survival in head and neck squamous cell carcinoma

Journal of Translational Medicine

Research

Joon-Yong Chung¹  Seung-Mo Hong²  Christopher A Moskaluk³  Kris Ylaya⁴  Hanbyoul Cho⁴  Ran Xie⁴  Mikiko Takikita⁴  Stephen M Hewitt⁵ 

[1] Applied Molecular Pathology Laboratory, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, 20892, Bethesda, MD, USA;Department of Pathology, Johns Hopkins Medical Institutions, 21287, Baltimore, MD, USA;Department of Pathology, University of Virginia Health System, 22908, Charlottesville, VA, USA;Tissue Array Research Program, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, 20892, Bethesda, MD, USA;Tissue Array Research Program, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, 20892, Bethesda, MD, USA;Applied Molecular Pathology Laboratory, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, 20892, Bethesda, MD, USA;

关键词: Epidermal Growth Factor Receptor;    Human Epidermal Growth Factor Receptor;    Her3 Expression;    Epidermal Growth Factor Receptor Family;    Her2 Protein Expression;   

DOI  :  10.1186/1479-5876-9-126

 received in 2011-03-10, accepted in 2011-07-29,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundHead and neck squamous cell carcinoma (HNSCC) still remains a lethal malignancy benefiting from the identification of the new target for early detection and/or development of new therapeutic regimens based on a better understanding of the biological mechanism for treatment. The overexpression of Her2 and Her3 receptors have been identified in various solid tumors, but its prognostic relevance in HNSCC remains controversial.MethodsThree hundred eighty-seven primary HNSCCs, 20 matching metasis and 17 recurrent HNSCCs were arrayed into tissue microarrays. The relationships between Her2 and Her3 protein expression and clinicopathological parameters/survival of HNSCC patients were analyzed with immunohistochemistry.ResultsHer3 is detected as either a cytoplasmic or a membranous dominant expression pattern whereas Her2 expression showed uniform membranous form. In primary tumor tissues, high membranous Her2 expression level was found in 104 (26.9%) cases while positive membranous and cytoplasmic Her3 expression was observed in 34 (8.8%) and 300 (77.5%) samples, respectively. Membranous Her2 expression was significantly associated with histological grade (P = 0.021), as grade 2 tumors showed the highest positive expression. Membranous Her3 over-expression was significantly prevalent in metastatic tissues compared to primary tumors (P = 0.003). Survival analysis indicates that membranous Her3 expression is significantly associated with worse overall survival (P = 0.027) and is an independent prognostic factor in multivariate analysis (hazard ratio, 1.51; 95% confidence interval, 1.01-2.23; P = 0.040).ConclusionsThese results suggest that membranous Her3 expression is strongly associated with poor prognosis of patients with HNSCC and is a potential candidate molecule for targeted therapy.

【 授权许可】

Unknown   
© Takikita et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.