Caveolin-1 in the regulation of cell metabolism: a cancer perspective

Molecular Cancer

Review

Matthias Philip Ebert¹  Steven Dooley²  Christoph Meyer²  Zeribe Chike Nwosu² 

[1] Department of Medicine II, Medical Faculty Mannheim, University of Heidelberg, 68167, Mannheim, Germany;Department of Medicine II, Medical Faculty Mannheim, University of Heidelberg, 68167, Mannheim, Germany;Molecular Hepatology Section, Medical Faculty Mannheim, University of Heidelberg, 68167, Mannheim, Germany;

关键词: CAV1;    Glycolysis;    Glutaminolysis;    Mitochondrion;    Fatty acid metabolism;    Autophagy;    Metabolic targets;   

DOI  :  10.1186/s12943-016-0558-7

 received in 2016-08-11, accepted in 2016-11-03,  发布年份 2016

来源: Springer

【 摘 要 】

Caveolin-1 (CAV1) is an oncogenic membrane protein associated with endocytosis, extracellular matrix organisation, cholesterol distribution, cell migration and signaling. Recent studies reveal that CAV1 is involved in metabolic alterations – a critical strategy adopted by cancer cells to their survival advantage. Consequently, research findings suggest that CAV1, which is altered in several cancer types, influences tumour development or progression by controlling metabolism. Understanding the molecular interplay between CAV1 and metabolism could help uncover druggable metabolic targets or pathways of clinical relevance in cancer therapy. Here we review from a cancer perspective, the findings that CAV1 modulates cell metabolism with a focus on glycolysis, mitochondrial bioenergetics, glutaminolysis, fatty acid metabolism, and autophagy.

【 授权许可】

CC BY   
© The Author(s). 2016