An epidemiological study to assess Plasmodium falciparum parasite prevalence and malaria control measures in Burkina Faso and Senegal

Malaria Journal

Research

Alphonse Ouedraogo¹  Espérance Ouedraogo¹  Alfred Tiono¹  Amidou Diarra¹  Sodiomon Sirima¹  Khadime Sylla²  Roger Tine²  Babacar Faye²  Assane Ndiaye³  Cheikh Sokhna³  El Hadji Ba³  Mahmadou Ndiaye³  Aldiouma Diallo³  Boubacar Coulibaly⁴  Mamadou Bountogo⁴  Ali Sié⁴  Guillaume Compaore⁴  Maurice Yé⁴  Melanie De Boer⁵  Jean-Yves Pirçon⁵  Effua Abigail Usuf⁵  Edith Roset Bahmanyar⁶ 

[1] Centre National de Recherche et de Formation sur le Paludisme (CNRFP), Ouagadougou, Burkina Faso;Centre de Recherche de Koer Socé, Service de Parasitologie Médicale, Faculté de Médecine, Université Cheikh Anta Diop, Dakar, Senegal;Centre de Recherche de Niakhar, Institut de Recherche pour le Développement, Dakar, Senegal;Centre de Recherche en Santé de Nouna, Nouna, Burkina Faso;GSK Vaccines, Wavre, Belgium;Profa Foundation, Vaud, Switzerland;

关键词: Malaria;    Burkina Faso;    Senegal;    Epidemiological study;    Parasite prevalence;    Risk factors;    Preventive interventions;   

DOI  :  10.1186/s12936-017-1715-1

 received in 2016-10-27, accepted in 2017-01-28,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundMalariometric information is needed to decide how to introduce malaria vaccines and evaluate their impact in sub-Saharan African countries.MethodsThis cross-sectional study (NCT01954264) was conducted between October and November, 2013, corresponding to the high malaria transmission season, in four sites with Health and Demographic Surveillance Systems (DSS) [two sites with moderate-to-high malaria endemicity in Burkina Faso (Nouna and Saponé) and two sites with low malaria endemicity in Senegal (Keur Socé and Niakhar)]. Children (N = 2421) were randomly selected from the DSS lists of the study sites and were stratified into two age groups (6 months–4 years and 5–9 years). A blood sample was collected from each child to evaluate parasite prevalence of Plasmodium falciparum and other Plasmodium species and gametocyte density by microscopy, and rapid diagnosis test in the event of fever within 24 h. Case report forms were used to evaluate malaria control measures and other factors.ResultsPlasmodium falciparum was identified in 707 (29.2%) children, with a higher prevalence in Burkina Faso than Senegal (57.5 vs 0.9% of children). In Burkina Faso, prevalence was 57.7% in Nouna and 41.9% in Saponé in the 6 months–4 years age group, and 75.4% in Nouna and 70.1% in Saponé in the 5–9 years age group. Infections with other Plasmodium species were rare and only detected in Burkina Faso. While mosquito nets were used by 88.6–97.0 and 64.7–80.2% of children in Burkina Faso and Senegal, other malaria control measures evaluated at individual level were uncommon. In Burkina Faso, exploratory analyses suggested that use of malaria treatment or any other medication within 14 days, and use of insecticide spray within 7 days decreased the prevalence of malaria infection; older age, rural residence, natural floor, grass/palm roof, and unavailability of electricity in the house were factors associated with increased malaria occurrence.ConclusionsPlasmodium falciparum infection prevalence in children younger than 10 years was 57.5% in Burkina Faso and 0.9% in Senegal, and variability was observed, among others, by age, study site and malaria control measures.

【 授权许可】

CC BY   
© The Author(s) 2017