Prognostic factors affecting the clinical outcome of carcinoma ex pleomorphic adenoma in the major salivary gland

World Journal of Surgical Oncology

Research

Liang Guo¹  Jiafeng Wang¹  Zhong Liang¹  Jianqiang Zhao¹  Kejing Wang¹  Jianlin Lou¹  Chang Yu² 

[1] Department of Head and Neck Surgery, Zhejiang Cancer Hospital, 38 Guangji Road, 310022, Hangzhou, Zhejiang, China;Department of Pathology, Zhejiang Cancer Hospital, 310022, Zhejiang, China;

关键词: Carcinoma ex pleomorphic adenoma;    Prognosis;    Salivary gland;    Pleomorphic carcinoma;    Survival;   

DOI  :  10.1186/1477-7819-11-180

 received in 2013-03-20, accepted in 2013-07-27,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundCarcinoma ex pleomorphic adenoma (CXPA) is an uncommon malignant tumor with highly aggressive biological behavior. Our goal was to investigate the prognosis of CXPA in the major salivary glands and factors influencing it.MethodsWe retrospectively reviewed 51 patients diagnosed with CXPA of the major salivary glands between 1999 and 2006, comprising 36 males and 15 females, aged from 23 to 86 years. All patients underwent surgery with curative intention, and 21 received postoperative radiation therapy.ResultsOf the 51 patients, 39.2% developed locoregional recurrence and 27.5% developed distant metastases. Median follow-up was 54 months. At the time of analysis, 29 (56.9%) patients were deceased. Overall survival was 62.7% at 3 years and 50.3% at 5 years. Tumor-specific survival was 64.4% at 3 years and 53.5% at 5 years. Using chi-squared tests, invasiveness, T stage, lymph node involvement and clinical stage were found to be significantly associated with locoregional recurrence. Histological grade, invasiveness, lymph node involvement and perineural invasion were associated with distant metastases (P < 0.05). Cox analysis showed that T stage, lymph node involvement, histological grade and perineural invasion were independent prognostic factors for overall survival.ConclusionT stage, lymph node involvement, histological grade, perineural invasion and extent of invasion are important prognostic factors of CXPA in the major salivary glands. Surgery is the primary treatment modality for CXPA and postoperative radiation therapy may be used in patients with factors for poor prognosis.

【 授权许可】

CC BY   
© Zhao et al.; licensee BioMed Central Ltd. 2013