Cinnamon extract induces tumor cell death through inhibition of NFκB and AP1

BMC Cancer

Research Article

Sung Haeng Lee¹  Chang-Rok Im²  Won Kyung Jeon³  Byoung Seob Ko³  Anupama Sahoo⁴  Zee Yong Park⁴  Ji-Sun Hwang⁴  Jae-Ha Ryu⁴  Ho-Keun Kwon⁴  Sin-Hyeog Im⁴  Choong-Gu Lee⁴  Jae-Seon So⁴ 

[1] Chosun University School of Medicine, 501-759, Gwangju, South Korea;Global leader program, Bugil Academy, 330-941, Cheonan, Gyeonggido, South Korea;Korea Institute of Oriental Medicine, 305-811, Daejeon, South Korea;School of Life Sciences and Immune Synapse Research Center, Gwangju Institute of Science and Technology (GIST), 1 Oryong-dong, 500-712, Puk-ku, Gwangju, South Korea;

关键词: Melanoma;    B16F10 Cell;    Mouse Melanoma;    Induce Growth Inhibition;    Cinnamon Extract;   

DOI  :  10.1186/1471-2407-10-392

 received in 2009-12-10, accepted in 2010-07-24,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundCinnamomum cassia bark is the outer skin of an evergreen tall tree belonging to the family Lauraceae containing several active components such as essential oils (cinnamic aldehyde and cinnamyl aldehyde), tannin, mucus and carbohydrate. They have various biological functions including anti-oxidant, anti-microbial, anti-inflammation, anti-diabetic and anti-tumor activity. Previously, we have reported that anti-cancer effect of cinnamon extracts is associated with modulation of angiogenesis and effector function of CD8+ T cells. In this study, we further identified that anti-tumor effect of cinnamon extracts is also link with enhanced pro-apoptotic activity by inhibiting the activities NFκB and AP1 in mouse melanoma model.MethodsWater soluble cinnamon extract was obtained and quality of cinnamon extract was evaluated by HPLC (High Performance Liquid Chromatography) analysis. In this study, we tested anti-tumor activity and elucidated action mechanism of cinnamon extract using various types of tumor cell lines including lymphoma, melanoma, cervix cancer and colorectal cancer in vitro and in vivo mouse melanoma model.ResultsCinnamon extract strongly inhibited tumor cell proliferation in vitro and induced active cell death of tumor cells by up-regulating pro-apoptotic molecules while inhibiting NFκB and AP1 activity and their target genes such as Bcl-2, BcL-xL and survivin. Oral administration of cinnamon extract in melanoma transplantation model significantly inhibited tumor growth with the same mechanism of action observed in vitro.ConclusionOur study suggests that anti-tumor effect of cinnamon extracts is directly linked with enhanced pro-apoptotic activity and inhibition of NFκB and AP1 activities and their target genes in vitro and in vivo mouse melanoma model. Hence, further elucidation of active components of cinnamon extract could lead to development of potent anti-tumor agent or complementary and alternative medicine for the treatment of diverse cancers.

【 授权许可】

Unknown   
© Kwon et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.