Malignant acanthosis nigricans: an early diagnostic clue for gastric adenocarcinoma

World Journal of Surgical Oncology

Case Report

Yu-Ling Shi¹  Xiu-Li Li¹  Qian Yu¹  Yu Gong¹  Hui Xu¹  Yao Wang¹  Guo Ji² 

[1] Department of Dermatology, Shanghai Tenth People’s Hospital9, Tongji University School of Medicine, No.301, Middle Yanchang Road, 200072, Shanghai, China;Department of Pathology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, 200072, Shanghai, China;

关键词: Malignant acanthosis nigricans;    Hyperkeratosis;    Papillomatosis;    Gastric adenocarcinoma;   

DOI  :  10.1186/s12957-017-1274-5

 received in 2017-07-14, accepted in 2017-11-15,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundMalignant acanthosis nigricans (MAN), characterized by the presence of a hyperpigmented, velvety cutaneous thickening, is recognized as a cutaneous sign of internal malignancy. Few MAN has been reported in the Asian race ever before.Case presentationHere, we report a rare case of MAN with severe mucosa and soles and extraordinary facial involvement in the Asian race. A 74-year-old man presented with hyperkeratotic eruption for 7 months. Physical examination revealed hyperkeratotic plaques on the face, dorsal skin of fingers and heels, and papillomatosis of buccal mucosa. Biopsy findings from skin lesion revealed hyperkeratosis, papillomatosis, and hyperpigmentation of the basal layer. The endoscopic ultrasound with biopsy of the gastric tissue revealed gastric cardia tubular adenocarcinoma. The patient was diagnosed with MAN associated with gastric adenocarcinoma, immediately following tumor resection and lymphadenectomy. A slight improvement was seen in the skin condition but died of cancer cachexia 3 months later.ConclusionsWe report our typical patient to highlight the importance of MAN, which was an early clue to the discovery of gastric adenocarcinoma.

【 授权许可】

CC BY   
© The Author(s). 2017