Adaptation and validation of the Charlson Index for Read/OXMIS coded databases

BMC Family Practice

Research Article

Peter W Rose¹  Rafael Perera¹  Nada F Khan¹  Stephen Harper² 

[1] Department of Primary Health Care, University of Oxford, Old Road Campus, OX3 7LF, Oxford, UK;Mill Stream Surgery, Benson, OX10 6RL, Wallingford, UK;

关键词: Cancer Survivor;    Breast Cancer Survivor;    Comorbid Disease;    General Practice Research Database;    Charlson Index;   

DOI  :  10.1186/1471-2296-11-1

 received in 2009-09-23, accepted in 2010-01-05,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundThe Charlson comorbidity index is widely used in ICD-9 administrative data, however, there is no translation for Read/OXMIS coded data despite increasing use of the General Practice Research Database (GPRD). Our main objective was to translate the Charlson index for use with Read/OXMIS coded data such as the GPRD and test its association with mortality. We also aimed to provide a version of the comorbidity index for other researchers using similar datasets.MethodsTwo clinicians translated the Charlson index into Read/OXMIS codes. We tested the association between comorbidity score and increased mortality in 146 441 patients from the GPRD using proportional hazards models.ResultsThis Read/OXMIS translation of the Charlson index contains 3156 codes. Our validation showed a strong positive association between Charlson score and age. Cox proportional models show a positive increasing association with mortality and Charlson score. The discrimination of the logistic regression model for mortality was good (AUC = 0.853).ConclusionWe have translated a commonly used comorbidity index into Read/OXMIS for use in UK primary care databases. The translated index showed a good discrimination in our study population. This is the first study to develop a co-morbidity index for use with the Read/OXMIS coding system and the GPRD. A copy of the co-morbidity index is provided for other researchers using similar databases.

【 授权许可】

CC BY   
© Khan et al; licensee BioMed Central Ltd. 2010