Green tea extract catechin improves internal cardiac muscle relaxation in RCM mice

Journal of Biomedical Science

Research

Wen Shen¹  Xupei Huang¹  Zhengyu Zhang¹  Changlong Nan¹  Gang Wu²  Yimin Hua²  Xiaoqin Wang³ 

[1] Department of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, 777 Glades Road, 33431, Boca Raton, FL, USA;Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, 610041, Chengdu, Sichuan, China;Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, 610041, Chengdu, Sichuan, China;Department of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, 777 Glades Road, 33431, Boca Raton, FL, USA;

关键词: Diastolic dysfunction;    Restrictive cardiomyopathy;    Calcium desensitization;    Green tea extracts;    Pressure-volume relationship;    Experimental animals;   

DOI  :  10.1186/s12929-016-0264-1

 received in 2016-02-25, accepted in 2016-05-24,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundDiastolic dysfunction refers to an impaired relaxation and an abnormality in a heart’s filling during diastole while left ventricular systolic function is preserved. Diastolic dysfunction is commonly observed in patients with primary hypertension, diabetes and cardiomyopathies such as hypertrophic cardiomyopathy or restrictive cardiomyopathy. We have generated a restrictive cardiomyopathy (RCM) mouse model with troponin mutations in the heart to mimic the human RCM patients carrying the same mutations.ResultsIn the present study, we have investigated the ventricular muscle internal dynamics and pressure developed during systole and diastole by inserting a micro-catheter into the left ventricle of the RCM mice with or without treatment of desensitizer green tea extracts catechins. Our results demonstrate that green tea catechin is able to correct diastolic dysfunction in RCM mainly by improving ventricular compliance and reducing the internal muscle rigidity caused by myofibril hypersensitivity to Ca2+.ConclusionGreen tea extract catechin is effective in correcting diastolic dysfunction and improving ventricular muscle intrinsic compliance in RCM caused by troponin mutations.

【 授权许可】

CC BY   
© The Author(s). 2016