Viruses exacerbating chronic pulmonary disease: the role of immune modulation

BMC Medicine

Review

Priya V Joshi¹  Patrick Mallia²  Sebastian L Johnston²  Aran Singanayagam² 

[1] Imperial College Healthcare NHS Trust, Praed Street, W2 1NY, London, UK;Imperial College London, National Heart and Lung Institute, Norfolk Place, W2 1PG, London, UK;Imperial College Healthcare NHS Trust, Praed Street, W2 1NY, London, UK;

关键词: Asthma;    cystic fibrosis;    chronic obstructive pulmonary disease;    respiratory viruses;    rhinovirus;    interferon;   

DOI  :  10.1186/1741-7015-10-27

 received in 2011-11-02, accepted in 2012-03-15,  发布年份 2012

来源: Springer

【 摘 要 】

Chronic pulmonary diseases are a major cause of morbidity and mortality and their impact is expected to increase in the future. Respiratory viruses are the most common cause of acute respiratory infections and it is increasingly recognized that respiratory viruses are a major cause of acute exacerbations of chronic pulmonary diseases such as asthma, chronic obstructive pulmonary disease and cystic fibrosis. There is now increasing evidence that the host response to virus infection is dysregulated in these diseases and a better understanding of the mechanisms of abnormal immune responses has the potential to lead to the development of new therapies for virus-induced exacerbations. The aim of this article is to review the current knowledge regarding the role of viruses and immune modulation in chronic pulmonary diseases and discuss avenues for future research and therapeutic implications.

【 授权许可】

Unknown   
© Singanayagamn et al; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.