Interfacial film stabilized W/O/W nano multiple emulsions loaded with green tea and lotus extracts: systematic characterization of physicochemical properties and shelf-storage stability

Journal of Nanobiotechnology

Research

Naveed Akhtar¹  Tariq Mahmood²  Sivakumar Manickam³ 

[1] Department of Pharmacy, Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, 63100, Bahawalpur, Pakistan;Department of Pharmacy, Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, 63100, Bahawalpur, Pakistan;School of Pharmacy, The University of Faisalabad, 37610, Faisalabad, Pakistan;Manufacturing and Industrial Processes Research Division, Faculty of Engineering, University of Nottingham Malaysia Campus, Jalan Broga, 43500, Semenyih, Malaysia;

关键词: Green tea;    Lotus;    Nano;    Multiple;    Emulsions;    Stability;   

DOI  :  10.1186/1477-3155-12-20

 received in 2013-12-13, accepted in 2014-04-29,  发布年份 2014

来源: Springer

【 摘 要 】

Background and aimsMultiple emulsions have excellent encapsulating potential and this investigation has been aimed to encapsulate two different plant extracts as functional cosmetic agents in the W/O/W multiple emulsions and the resultant system’s long term stability has been determined in the presence of a thickener, hydroxypropyl methylcellulose (HPMC).MethodsMultiple W/O/W emulsions have been generated using cetyl dimethicone copolyol as lipophilic emulsifier and a blend of polyoxyethylene (20) cetyl ether and cetomacrogol 1000® as hydrophilic emulsifiers. The generated multiple emulsions have been characterized with conductivity, pH, microscopic analysis, phase separation and rheology for a period of 30 days. Moreover, long term shelf-storage stability has been tested to understand the shelf-life by keeping the generated multiple emulsion formulations at 25 ± 10°C and at 40 ± 10% relative humidity for a period of 12 months.ResultsIt has been observed that the hydrophilic emulsifiers and HPMC have considerably improved the stability of multiple emulsions for the followed period of 12 months at different storage conditions. These multiple emulsions have shown improved entrapment efficiencies concluded on the release rate of conductometric tracer entrapped in the inner aqueous phase of the multiple emulsions.ConclusionMultiple emulsions have been found to be stable for a longer period of time with promising characteristics. Hence, stable multiple emulsions loaded with green tea and lotus extracts could be explored for their cosmetic benefits.

【 授权许可】

CC BY   
© Mahmood et al.; licensee BioMed Central Ltd. 2014