A peculiar case report of extraovarian Brenner tumor arising in the omentum

World Journal of Surgical Oncology

Case Report

Ahrong Kim¹  Do Youn Park¹  Young Geum Kim¹  Chang Hun Lee¹  Hyun Jeong Kang²  Dong Hoon Shin³  So Jeong Lee³  Chung Su Hwang³ 

[1] Department of Pathology and Medical Research Institute, Pusan National University Hospital, Busan, Republic of Korea;Department of Pathology, Munhwa Hospital, Busan, Republic of Korea;Department of Pathology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea;

关键词: Brenner tumor;    Extraovarian;    Omentum;   

DOI  :  10.1186/s12957-017-1135-2

 received in 2016-09-27, accepted in 2017-03-22,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundBrenner tumors almost always develop in the ovary. Exceptionally, extraovarian Brenner tumors have been reported in the lower abdomen or pelvic organs. Here, we introduce a peculiar case of an extraovarian Brenner tumor arising in the omentum.Case presentationA 43-year-old woman presented with a palpable abdominal mass. Computed tomography (CT) scan revealed a 9.0-cm solid mass in the omentum. The tumor was not associated with pelvic structures, including the ovaries. It was excised under the clinical impression of an extragastrointestinal stromal tumor or neurogenic tumor. Grossly, the mass was a well-circumscribed solid tumor, with yellow-tan cut surface and minute cystic spaces. Microscopically, the tumor showed well-defined epithelial nests with variable cystic changes embedded in an abundant fibrous stroma. The cells within the nests were reminiscent of benign urothelial cells in that they had oval, frequently grooved nuclei. The epithelial cells focally showed a gradual transition into the surrounding stromal cells with short spindled features. The urothelium-like cells were positive for pancytokeratin, WT-1, p63, CK7, uroplakin-III, and GATA-3 but were negative for CD34, CD10, CK20, c-KIT, DOG-1, PAX-8, and calretinin. Morphological and immunohistochemical features of the tumor were the same as an ovarian Brenner tumor, and so it was diagnosed as an extraovarian Brenner tumor.ConclusionsAlthough the location of the tumor was very unusual, we could diagnose the tumor as an extraovarian Brenner tumor on the basis of the histologic and immunohistochemical findings. This is the first case of extraovarian Brenner tumor arising in the omentum near the stomach ever reported in the English literature.

【 授权许可】

CC BY   
© The Author(s). 2017