NephroCheck data compared to serum creatinine in various clinical settings

BMC Nephrology

Research Article

Wilfred Druml¹  Ludwig Wagner¹  Sahra Pajenda¹  Aysegül Ilhan-Mutlu²  Matthias Preusser²  Sebastian Roka³ 

[1] Division of Nephrology and Dialysis, Department of Internal Medicine III, Vienna General Hospital, Waehringer Guertel 18-20, 1090, Vienna, Austria;Division of Oncology, Department of Internal Medicine I, Vienna General Hospital, Waehringer Guertel 18-20, 1090, Vienna, Austria;Division of Transplant Surgery, Department of Surgery, Vienna General Hospital, Waehringer Guertel 18-20, 1090, Vienna, Austria;

关键词: Acute kidney injury;    IGFBP7;    NephroCheck;    TIMP-2;   

DOI  :  10.1186/s12882-015-0203-5

 received in 2015-07-17, accepted in 2015-11-30,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundAcute kidney injury is frequently observed at the intensive care unit, after surgery, and after toxic drug administration. A rise in serum creatinine and a fall in urine output are consequences of much earlier injury to the most sensitive part of tubular cells located at the proximal tubule. The aim of the present study was to investigate the course of two cell-cycle arrest urinary biomarkers compared to serum creatinine in four clinical settings: ischemic reperfusion injury, cardiac failure, severe acute kidney injury, and chemotherapy-induced kidney injury.MethodsA recently developed bedside test known as NephroCheck measures two urinary parameters: insulin-like growth factor binding protein 7 (IGFBP7) and tissue inhibitor of metalloproteinase-2 (TIMP-2). The test is based on a sandwich immunoassay technique. The final test output, labeled AKIRisk, is shown as a numeric result.ResultsThis report revealed that [IGFBP7] · [TIMP-2] in urine rise rapidly prior to any change in serum creatinine. A unique feature of all four clinical settings is that a rapid decline predicts the recovery of kidney function. Besides, a subclinical kidney injury might be detected by the test.ConclusionThis bedside test detects biomarkers of renal injury. A rapid decline in AKIRisk was associated with the restoration of kidney function, whereas a prolonged high AKIRisk score was associated with end-stage renal disease. However, the dynamics seem to differ, depending on the cause and the extent of injury. Further studies will be needed to clarify the issue.

【 授权许可】

CC BY   
© Pajenda et al. 2015