Association of admission testosterone level with ST-segment resolution in male patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

Basic and Clinical Andrology

Research Article

Ahmad Separham¹  Samad Ghaffari¹  Hasanali Lotfollahi¹  Bahram Sohrabi¹  Naser Aslanabadi¹  Mozhgan Hadavi Bavil¹ 

[1] Cardiology Department, Cardiovascular Research Center, Tabriz University of Medical science, Madani Heart Center, Daneshgah Ave, Tabriz, Iran;

关键词: ST-segment elevation myocardial infarction;    Serum testosterone;    ST-segment resolution;    Primary percutaneous coronary intervention;    Infarctus du myocarde avec sus-décalage du segment ST;    Testostérone sérique;    Résolution du segment ST;    Intervention coronarienne percutanée précoce;   

DOI  :  10.1186/s12610-017-0058-7

 received in 2017-03-03, accepted in 2017-06-26,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundLow level of testosterone may be associated with cardiovascular diseases in men, as some evidence suggests a protective role for testosterone in cardiovascular system. Little is known about the possible role of serum testosterone in response to reperfusion therapy in ST-elevation myocardial infarction (STEMI) and its relationship with ST-segment recovery. The present study was conducted to evaluate the association of serum testosterone levels with ST-segment resolution following primary percutaneous coronary intervention (PPCI) in male patients with acute STEMI.MethodsForty-eight men (mean age 54.55 ± 12.20) with STEMI undergoing PPCI were enrolled prospectively. Single-lead ST segment resolution in the lead with maximum baseline ST-elevation was measured and patients were divided into two groups according to the degree of ST-segment resolution: complete (> or =50%) or incomplete (<50%). The basic and demographic data of all patients, their left ventricular ejection fraction (LVEF) and laboratory findings including serum levels of free testosterone and cardiac enzymes were recorded along with angiographic finding and baseline TIMI (Thrombolysis in Myocardial Infarction) flow and also in-hospital complications and then these variables were compared between two groups.ResultsA complete ST-resolution (≥50%) was observed in 72.9% of the patients. The serum levels of free testosterone (P = 0.04), peak cardiac troponin (P = 0.03) were significantly higher and hs-CRP (P = 0.02) were lower in patients with complete ST-resolution compared to those with incomplete ST-resolution. In-hospital complications were observed in 31.2% of patients. The patients with a lower baseline TIMI flow (P = 0.03) and those who developed complications (P = 0.04) had lower levels of free testosterone. A significant positive correlation was observed between the left ventricular function and serum levels of free testosterone (P = 0.01 and r = +0.362).ConclusionThis study suggests that in men with STEMI undergoing PPCI, higher serum levels of testosterone are associated with a better reperfusion response, fewer complications and a better left ventricular function.

【 授权许可】

CC BY   
© The Author(s). 2017