Resection of pancreatic ductal adenocarcinoma with synchronous distant metastasis: is it worthwhile?

World Journal of Surgical Oncology

Research

Johan Gagnière¹  Denis Pezet¹  Emmanuel Buc¹  Olivier Antomarchi¹  David Orry²  David Da Ines³ 

[1] Department of Digestive and HPB Surgery, CHU Estaing - 1, Place Lucie et Raymond Aubrac, 63003, Clermont-Ferrand, France;Department of Oncologic Surgery, Centre Georges François Leclerc, Dijon, France;Department of Radiology, CHU Estaing, Clermont-Ferrand, France;

关键词: Pancreatic cancer;    Metastasis;    Surgery;    Chemotherapy;    Survival;   

DOI  :  10.1186/1477-7819-12-347

 received in 2014-02-23, accepted in 2014-07-04,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundThe purpose of this study is to report prolonged survival in patients with metastatic pancreatic ductal adenocarcinoma (PDAC) managed by chemotherapy and surgery.MethodsBetween January 2009 and August 2013, 284 patients with metastatic PDAC were managed in our oncologic department. Among them, three (1%) with a single metastasis (liver in two cases and interaorticaval in one case) underwent one- or two-stage surgical resection of the metastasis and the main tumor. Perioperative data were recorded retrospectively, including disease-free and overall survival.ResultsThe three patients had chemotherapy (FOLFOX or FOLFIRINOX regimen) with objective response or stable disease prior to surgery. Median time between chemotherapy and surgery was 9 (8 to 15) months. Resection consisted in pancreaticoduodenectomy in the three cases. None of the patients had grade III/IV postoperative complications, and median hospital stay was 12 (12 to 22) days. All the patients had postoperative chemotherapy. Only one patient experienced recurrence 11 months after surgery and died after 32.5 months. The two other patients were alive with no recurrence 26.3 and 24.7 months after initial treatment.ConclusionRadical resection of PDAC with single distant metastases can offer prolonged survival with low morbidity after accurate selection by neoadjuvant chemotherapy.

【 授权许可】

CC BY   
© Buc et al.; licensee BioMed Central Ltd. 2014