The current incidence, prevalence, and residual risk of hepatitis B viral infections among voluntary blood donors in China

BMC Infectious Diseases

Research Article

Weifang Cheng¹  Yingjie Qi²  Libin Niu³  Ka Yi Li⁴  Liang Zang⁵  Yanhua Li⁶  Hongkeng Lin⁷  Ling Li⁸  Guojin Ou⁸  Zhong Liu⁹  Yuqiang Liu^1,10  Ruan Cao^1,11  Binghai Zhao^1,12  Tingting Han^1,13  Xiao Liu^1,14 

[1] Anhui Blood Center, Hefei, Anhui, China;Anhui Provincial Infection Hospital, Hefei, Anhui, China;Changzhi Blood Center, Changzhi, Shanxi, China;Cooper Medical School of Rowan University, Camden, USA;Dalian Blood Center, Dalian, Liaoning, China;Department of Pathology, New York University School of Medicine, NYU Langone Health, New York, USA;Fujian Blood Center, Fuzhou, Fujian, China;Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, Sichuan, China;Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, Sichuan, China;26 Huacai Rd, Longtan Industry Zone, Chenghua District, Chengdu, Sichuan, People’s Republic of China;Kaifeng Blood Center, Kaifeng, Henan, China;Mianyang Blood Center, Mianyang, Sichuan, China;Nanchong Blood Center, Nanchong, Sichuan, China;No. 1 People’s Hospital of Anqing, Anqing, Anhui, China;No. 1 People’s Hospital of Deyang, Deyang, Sichuan, China;

关键词: HBV;    Residual risk;    Transfusion;    Donors;   

DOI  :  10.1186/s12879-017-2861-3

 received in 2017-07-31, accepted in 2017-11-26,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThere are few data available on the prevalence, incidence, and residual risk of transfusion-transmitted HBV (TT-HBV) infections among Chinese blood donors. This study investigated the demographic characteristics of blood donors, as well as the prevalence, incidence, and residual risk (RR) of TT-HBV infections in six large blood centers in different regions of China.MethodsThe demographic characteristics and HBV screening test results of blood donors from six blood centers in different regions in China were collected and analyzed. The hepatitis B surface antigen (HBsAg) yield approach was used to estimate the incidence of HBV. Then, the RR of TT-HBV infections was evaluated using the incidence-window period model.ResultsThe majority of donors were between 18 and 35 years old (including 35), with the exception of the Changzhi Blood Center where a majority of donors were between 35 and 55 years old (including 55). The prevalences of HBV were 0.13%, 0.078%, 0.16%, 0.07%, 0.20%, 0.25% in Hefei, Dalian, Changzhi, Kaifeng, Mianyang and Fujian, respectively. The estimated corresponding incidences were 213.44, 161.59, 989.80, 278.05, 125.31 and 352.19 per 105 person-years. Using an infectious window period of 59 days, the RR for HBV was estimated to be 34.14, 25.85, 158.35, 44.48, 20.04 and 56.35 per 105 person-years in Hefei, Dalian, Changzhi, Kaifeng, Mianyang and Fujian, respectively.ConclusionDespite the introduction of more sensitive assays in blood screening, our data revealed that the current residual risk of TT-HBV infection was still high (overall 56.53 per 105 py). A continuous monitoring of the residual risk of transfusion-transmitted infections is crucial for safe blood management.

【 授权许可】

CC BY   
© The Author(s). 2017