The effects of EPA and DHA enriched fish oil on nutritional and immunological markers of treatment naïve breast cancer patients: a randomized double-blind controlled trial

Nutrition Journal

Research

Eduardo Yoshio Nakano¹  Maria Imaculada Muniz-Junqueira²  Kelly G. Magalhães³  Ana Carolina de M. Oliveira⁴  Nathalia Pizato⁴  Marina K. Ito⁴  Elemárcia Martins da Silva Paixão⁴ 

[1]Department of Statistics, University of Brasilia, 70910-900, Brasilia, Federal District, Brazil

[2]Laboratory of Cellular Immunology, Department of Pathology, Faculty of Medicine, University of Brasilia, 70910-900, Brasilia, Federal District, Brazil

[3]Laboratory of Immunology and Inflammation, Department of Cell Biology, Institute of Biology, University of Brasilia, 70910-900, Brasilia, Federal District, Brazil

[4]Post Graduate Program in Human Nutrition, University of Brasília, 70910-900, Brasilia, Federal District, Brazil

关键词: Breast cancer;    N-3 fatty acids;    Fish oil;    Immunonutrition;    Cytokines;    Eicosapentaenoic acid (EPA);   

DOI  :  10.1186/s12937-017-0295-9

 received in 2017-06-02, accepted in 2017-10-10,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundWe evaluated the effects of eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids enriched fish oil (FO) on nutritional and immunological parameters of treatment naïve breast cancer patients.MethodsIn a randomized double blind controlled trial, the FO group (FG) patients were supplemented with 2 g/ day of FO concentrate containing 1.8 g of n-3 fatty acids during 30 days. The placebo group (PG) received 2 g/ day of mineral oil. At baseline and after the intervention, plasma levels of n-3 fatty acids, dietary intake, weight, body composition, biochemical and immunological markers were assessed.ResultsAt the end of the intervention period, no between group differences were observed regarding anthropometric parameters. There was a significant increase in the plasma phospholipid EPA (p = 0.004), DHA (p = 0.007) of the FG patients. In FG patients the percentages of peripheral blood CD4+ T lymphocytes and serum high sensitivity C-reactive protein (hsCRP) levels were maintained while in PG patients there was a significant increase in hsCRP (p = 0.024). We also observed a significant reduction in the percentage of CD4+ T lymphocytes in the peripheral blood (p = 0.042) of PG patients. No changes in serum proinflammatory cytokine and prostaglandin E2 levels were observed.ConclusionsSupplementation of newly diagnosed breast cancer patients with EPA and DHA led to a significant change in the composition of plasma fatty acids, maintained the level of CD4+ T cells and serum levels of hsCRP, suggestive of a beneficial effect on the immune system and less active inflammatory response.Trial registrationBrazilian Clinical Trials Registry (REBEC): RBR-2b2hqh. Registered 29 April 2013, retrospectively registered.

【 授权许可】

CC BY   
© The Author(s). 2017