期刊论文详细信息
Nutrition Journal
Oral intake of a combination of glucosyl hesperidin and caffeine elicits an anti-obesity effect in healthy, moderately obese subjects: a randomized double-blind placebo-controlled trial
Research
Yoshihiro Yamamoto1  Koutarou Muroyama1  Tatsuya Ohara1  Shinji Murosaki1 
[1] Research & Development Institute, House Wellness Foods Corporation, 3-20 Imoji, 664-0011, Itami, Hyogo, Japan;
关键词: Glucosyl hesperidin;    Caffeine;    Obesity;    Body fat;    Body mass index;   
DOI  :  10.1186/s12937-016-0123-7
 received in 2015-10-19, accepted in 2016-01-08,  发布年份 2016
来源: Springer
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【 摘 要 】

BackgroundWe have previously shown that a combination of glucosyl hesperidin (G-hesperidin) plus caffeine reduces accumulation of body fat, whereas G-hesperidin or caffeine alone shows little effect on high-fat diet-induced obesity in mice. The aim of this study is to evaluate the anti-obesity effect of G-hesperidin plus caffeine on body fat and serum TG in healthy subjects with moderately high body mass index (BMI) and serum TG. Since we considered that there are individual differences in caffeine sensitivity, we conducted dose-finding study of caffeine combined with G-hesperidin.MethodsSeventy-five healthy subjects with moderately high BMI (24–30 kg/m2) and serum TG (100–250 mg/dl) were divided and assigned to 12-week intervention with daily intakes of 500 mg of G-hesperidin with or without 25, 50, or 75 mg of caffeine, or placebo in a randomized double-blind placebo-controlled design .ResultsAfter intervention, decreases in abdominal fat area (AFA), especially subcutaneous fat area (SFA), were significantly greater in the G-hesperidin with 50-mg caffeine group (AFA:-8.4 ± 21.9 v.s. 16.3 ± 34.1 cm2; p < 0.05, SFA: -9.3 ± 17.1 v.s. 11.2 ± 18.3 cm2; p < 0.01) and in the G-hesperidin with 75-mg caffeine group (AFA:-17.0 ± 31.4 v.s. 16.3 ± 34.1 cm2; p < 0.01, SFA: -12.4 ± 18.7 v.s. 11.2 ± 18.3 cm2; p < 0.01) than in the placebo group. Fat-decreasing effects of G-hesperidin were enhanced dose-dependently by caffeine addition. BMI decreases were significantly greater in the G-hesperidin with 75-mg caffeine group than in the placebo group (-0.56 ± 0.74 v.s. -0.02 ± 0.58 kg/m2; p < 0.05). G-hesperidin with/without caffeine had no effect on serum TG (p > 0.05 v.s. placebo).ConclusionsThese data suggested that a combination of 500-mg G-hesperidin with 50- or 75-mg caffeine may be useful for the prevention or treatment of obesity.Trial registrationUMIN Clinical Trials Registry 000019241.

【 授权许可】

CC BY   
© Ohara et al. 2016

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【 参考文献 】
  • [1]
  • [2]
  • [3]
  • [4]
  • [5]
  • [6]
  • [7]
  • [8]
  • [9]
  • [10]
  • [11]
  • [12]
  • [13]
  • [14]
  • [15]
  • [16]
  • [17]
  • [18]
  • [19]
  • [20]
  • [21]
  • [22]
  • [23]
  • [24]
  • [25]
  • [26]
  • [27]
  • [28]
  • [29]
  • [30]
  • [31]
  • [32]
  • [33]
  • [34]
  • [35]
  • [36]
  • [37]
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