Dietary intake of n-3 PUFAs modifies the absorption, distribution and bioavailability of fatty acids in the mouse gastrointestinal tract

Lipids in Health and Disease

Research

Yunqi Ji¹  Shunhe Wang¹  Wei Chen²  Qin Yang²  Hao Zhang²  Haiqin Chen²  Zhennan Gu³  Yong Q. Chen³ 

[1]State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, 214122, Wuxi, People’s Republic of China

[2]State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, 214122, Wuxi, People’s Republic of China

[3]Synergistic Innovation Center for Food Safety and Nutrition, 214122, Wuxi, People’s Republic of China

[4]State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, 214122, Wuxi, People’s Republic of China

[5]Synergistic Innovation Center for Food Safety and Nutrition, 214122, Wuxi, People’s Republic of China

[6]Department of Cancer Biology and Biochemistry, Wake Forest School of Medicine, 27157, Winston-Salem, NC, USA

关键词: n-3 PUFA;    SFA;    Gut;    Distribution;    Bioavailability;    Absorption;   

DOI  :  10.1186/s12944-016-0399-9

 received in 2016-08-02, accepted in 2016-12-26,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundDietary polyunsaturated fatty acids (PUFAs), especially n-3 PUFAs, are important for human health. The intestinal tract, a location that is heavily colonized by microorganisms, is the main organ for absorbing fatty acids.MethodsThe purpose of this study was to analyze the effects of dietary n-3 and n-6 PUFAs on the distribution of different types of fatty acids and their bioavailability along the gut. Mice were fed for a week with experimental diets containing high n-3 or high n-6 fatty acid levels. Blood was collected at different time points, and after 7 days the mice were euthanized and their digestive tract was divided into 17 segments for fatty acids analyses.ResultsWe found that supplementing n-3 fatty acids significantly changed the ratio of n-6/n-3 PUFAs, increased the bioavailability of n-3 PUFAs, and altered fatty acid distribution. In addition, in the n-3 diet group, the absorption of saturated fatty acids (SFAs) along the gut was found to be inhibited, which was confirmed by feeding the mice with a diet containing deuterium-labeled palmitic acid and stearic acid.ConclusionThese results show that a diet rich in n-3 PUFAs can significantly modify the distribution and bioavailability of fatty acids, and particularly, may block the absorption of SFAs in the mouse gastrointestinal (GI) tract.

【 授权许可】

CC BY   
© The Author(s). 2017

【 图 表 】

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