Wall motion in the stenotic carotid artery: association with greyscale plaque characteristics, the degree of stenosis and cerebrovascular symptoms

Cardiovascular Ultrasound

Research

Baris Kanber¹  Mark A Horsfield¹  Andrew R Naylor²  Timothy C Hartshorne²  Thompson G Robinson³  Kumar V Ramnarine⁴ 

[1] Department of Cardiovascular Sciences, University of Leicester, Leicester, UK;Department of Cardiovascular Sciences, University of Leicester, Leicester, UK;Department of Surgery, University Hospitals of Leicester NHS Trust, Leicester, UK;Department of Cardiovascular Sciences, University of Leicester, Leicester, UK;NIHR Biomedical Research Unit for Cardiovascular Sciences, University of Leicester, Leicester, UK;Department of Medical Physics, University Hospitals of Leicester NHS Trust, LE1 5WW, Leicester, UK;

关键词: Ultrasound;    Carotid artery;    Carotid plaque;    Stenosis;    Wall motion;    Distension;    Dilation;    Greyscale median;    GSM;    Surface irregularity index;    SII;    Cerebrovascular symptoms;   

DOI  :  10.1186/1476-7120-11-37

 received in 2013-09-05, accepted in 2013-10-04,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundSystolic dilation of the atherosclerotic carotid artery depends on several factors including arterial compliance and the haemodynamic environment. The purpose of this study was to quantify wall motion in stenotic carotid arteries and investigate any associations with the ultrasound greyscale plaque characteristics, the degree of stenosis, and the presence of cerebrovascular symptoms.MethodsVariations in the lumen diameters of 61 stenotic carotid arteries (stenosis range 10%-95%) from 47 patients were measured before the proximal shoulder of the atherosclerotic plaque using ultrasound image sequences over several cardiac cycles. Absolute and percentage diameter changes from diastole to systole were calculated and their relationship to the degree of stenosis, greyscale plaque characteristics, and the presence of ipsilateral hemispheric symptoms were studied.ResultsThe mean absolute diameter change from diastole to systole was 0.45 mm (s.d. 0.17), and the mean percentage diameter change was 6.9% (s.d. 3.1%). Absolute and percentage diameter changes did not have a statistically significant relationship to the degree of stenosis, greyscale plaque characteristics, or the presence of ipsilateral hemispheric symptoms (p > 0.05). Parameters significantly correlated with the presence of symptoms were the degree of stenosis (p = 0.01), plaque greyscale median (p = 0.02) and the plaque surface irregularity index (p = 0.02).ConclusionsOur study confirmed the degree of stenosis, plaque greyscale median and our surface irregularity index were significant predictors of symptoms, but found no significant correlation between diameter changes of stenosed carotid arteries and the presence of ipsilateral hemispheric symptoms.

【 授权许可】

Unknown   
© Kanber et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.