Metals and trace element concentrations in breast milk of first time healthy mothers: a biological monitoring study

Environmental Health

Research

Marika Berglund¹  Brita Palm¹  Karin Ljung Björklund¹  Marie Vahter¹  Margaretha Grandér¹  Sanna Lignell² 

[1] Institute of Environmental Medicine, Karolinska Institutet, PO Box 210, 171 77, Stockholm, SE, Sweden;National Food Agency, PO Box 622, 751 26, Uppsala, SE, Sweden;

关键词: Breast milk;    Toxic metals;    Trace elements;    Infant exposure;    Microelements;    Macroelements;   

DOI  :  10.1186/1476-069X-11-92

 received in 2012-07-31, accepted in 2012-12-10,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundBreast milk is the best source of nutrition for the newborn infant. However, since all infants cannot be breast-fed, there is a need for background data for setting adequate daily intakes. Previously, concentration data on major essential elements and some toxic elements in breast milk, based on different analytical techniques, have been published. There is no recent study on a large number of metals and trace elements in breast milk, using a sensitive analytical method for determination of low element concentrations.MethodsBreast milk concentrations of 32 metals and elements in early lactation (days 14-21) were determined in a random sample of first time Swedish mothers (n = 60) using inductively coupled plasma mass spectrometry (ICPMS).ResultsThere were small inter-individual concentration variations in the macroelements Ca, K, Mg, P and S, and striking similarities across studies and over time, supporting a tight regulation of these elements in breast milk. Large inter-individual and over time differences were detected for Na concentrations, which may reflect an increase in salt consumption in Swedish women. Large inter-individual differences were also detected for the microelements Co, Cr, Mn and Mo, and the toxic metals As, Cd, Pb, Sb and V. Arsenic and B were positively correlated with fish consumption, indicating influence of maternal intake on breast milk concentrations. Observed differences in breast milk element concentrations across studies and over time could be attributed to the timing of sampling and a general decline over time of lactation (Cu, Fe, Mo, Zn), a possible lack of regulation of certain elements in breast milk (As, B, Co, Mn, Se) and time trends in environmental exposure (Pb), or in some cases to differences in analytical performance (Cr, Fe).ConclusionsThis study provides reliable updated information on a number of metals and elements in breast milk, of which some have not previously been reported.

【 授权许可】

Unknown   
© Ljung Björklund et al; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.