Consumption of coffee associated with reduced risk of liver cancer: a meta-analysis

BMC Gastroenterology

Research Article

Li-Xuan Sang¹  Bing Chang²  Min Jiang²  Xiao-Hang Li³ 

[1] Department of Cadre Ward II, First Affiliated Hospital of China Medical University, No.155, Nanjing North Street, Heping District, 110001, Liaoning Province, Shenyang, China;Department of Gastroenterology, First Affiliated Hospital of China Medical University, No.155, Nanjing North Street, Heping District, 110001, Liaoning Province, Shenyang, China;Department of General Surgery, First Affiliated Hospital of China Medical University, No.155, Nanjing North Street, Heping District, 110001, Liaoning Province, Shenyang, China;

关键词: Coffee;    Epidemiology;    Liver cancer;    Meta-analysis;   

DOI  :  10.1186/1471-230X-13-34

 received in 2012-07-18, accepted in 2013-02-21,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundEpidemiologic studies have reported inconsistent results regarding coffee consumption and the risk of liver cancer. We performed a meta-analysis of published case–control and cohort studies to investigate the association between coffee consumption and liver cancer.MethodsWe searched Medline, EMBASE, ISI Web of Science and the Cochrane library for studies published up to May 2012. We performed a meta-analysis of nine case–control studies and seven cohort studies.ResultsThe summary odds ratio (OR) for high vs no/almost never drinkers was 0.50 (95% confidence interval (CI): 0.42–0.59), with no significant heterogeneity across studies (Q = 16.71; P = 0.337; I2 = 10.2%). The ORs were 0.50 (95% CI: 0.40–0.63) for case–control studies and 0.48 (95% CI: 0.38–0.62) for cohort studies. The OR was 0.38 (95% CI: 0.25–0.56) in males and 0.60 (95% CI: 0.33–1.10) in females. The OR was 0.45 (95% CI: 0.36–0.56) in Asian studies and 0.57 (95% CI: 0.44–0.75) in European studies. The OR was 0.39 (95% CI: 0.28–0.54) with no adjustment for a history of liver disease and 0.54 (95% CI: 0.46–0.66) after adjustment for a history of liver disease.ConclusionsThe results of this meta-analysis suggested an inverse association between coffee consumption and liver cancer. Because of the small number of studies, further prospective studies are needed.

【 授权许可】

Unknown   
© Sang et al; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.