Association between type 2 diabetes and chronic arsenic exposure in drinking water: A cross sectional study in Bangladesh

Environmental Health

Research

Roseanne Peel¹  Mark McEvoy¹  John Attia¹  Md Rafiqul Islam¹  Catherine D’Este¹  Abul Hasnat Milton¹  Munira Sultana²  Ismail Khan³  Sheikh Md Nazmul Hassan⁴  Shahnaz Akter⁵ 

[1] Centre for Clinical Epidemiology & Biostatistics (CCEB), The University of Newcastle, Lot 1 Kookaburra CircuitNSW, 2305, New Lambton Heights, Australia;Centre for Health and Development (CHAD), Gopalgonj, Bangladesh;Department of Pharmacology, Dhaka Medical College, Dhaka, Bangladesh;Department of Public Health, Atish Dipankar University of Science & Technology, Dhaka, Dhanmondi, Bangladesh;Institute of Child and Mother Health (ICMH), Dhaka, Bangladesh;

关键词: Arsenic;    Drinking Water;    Arsenic Concentration;    Arsenic Exposure;    Inorganic Arsenic;   

DOI  :  10.1186/1476-069X-11-38

 received in 2011-11-16, accepted in 2012-06-07,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundChronic exposure to high level of inorganic arsenic in drinking water has been associated with Type 2 Diabetes (T2D). Most research has been ecological in nature and has focused on high levels of arsenic exposure with few studies directly measuring arsenic levels in drinking water as an index of arsenic exposure. The effect of low to moderate levels of arsenic exposure on diabetes risk is largely unknown thus our study is adding further knowledge over previous works.MethodsThis cross sectional study was conducted in 1004 consenting women and men from 1682 eligible participants yielding a participation rate of 60%. These participants are aged > 30 years and were living in Bangladesh and had continuously consumed arsenic-contaminated drinking water for at least 6 months. T2D cases were diagnosed using glucometer following the new diagnostic criteria (Fasting Blood Glucose > 126 mg/dl) from the WHO guideline (WHO 2006), or a self-reported physician diagnosis of type 2 diabetes. Association between T2D and chronic arsenic exposure was estimated by multiple logistic regression with adjustment for age, sex, education, Body Mass Index (BMI) and family history of T2D.ResultsA total of 1004 individuals participated in the study. The prevalence of T2D was 9% (95% CI 7-11%). After adjustment for diabetes risk factors, an increased risk of type 2 diabetes was observed for arsenic exposure over 50 μg/L with those in the highest category having almost double the risk of type 2 diabetes (OR=1.9 ; 95% CI 1.1-3.5). For most levels of arsenic exposure, the risk estimates are higher with longer exposure; a dose–response pattern was also observed.ConclusionsThese findings suggest an association between chronic arsenic exposure through drinking water and T2D. Risks are generally higher with longer duration of arsenic exposure. The risk of T2D is highest among those who were exposed to the highest concentration of arsenic for more than 10 years.

【 授权许可】

Unknown   
© Islam et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.