Evaluation of three-dimensional SonoAVC ultrasound for antral follicle count in infertile women: its agreement with conventional two-dimensional ultrasound and serum levels of anti-Müllerian hormone

Reproductive Biology and Endocrinology

Research

R. Chapon¹  P. A. Peres Fagundes¹  J. S. Cunha-Filho²  A. K. Schuster³  P. R. Olsen³  M. M. C. Mattia⁴ 

[1] INSEMINE, Human Reproductive Center, Avenida Dr. Nilo Peçanha 2825, 91330-001, Porto Alegre, Brazil;UFRGS, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos 2350, 90035-903, Porto Alegre, Brazil;INSEMINE, Human Reproductive Center, Avenida Dr. Nilo Peçanha 2825, 91330-001, Porto Alegre, Brazil;UFRGS, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos 2350, 90035-903, Porto Alegre, Brazil;UFRGS, Universidade Federal do Rio Grande do Sul, Department of Gynecology and Obstetrics, Porto Alegre Clinical Hospital, Rua Ramiro Barcelos 2350, 90035-903, Porto Alegre, RS, Brazil;UFRGS, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos 2350, 90035-903, Porto Alegre, Brazil;UFRGS, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos 2350, 90035-903, Porto Alegre, Brazil;PPGGO, Graduate Program in Health Sciences: Gynecology and Obstetrics, Faculty of Medicine, UFRGS, Rua Ramiro Barcelos, 2400, 2° andar, 90035-003, Porto Alegre, Brazil;

关键词: Anti-Müllerian hormone;    Antral follicle count;    Infertility;    Transvaginal ultrasound;    3D SonoAVC;   

DOI  :  10.1186/s12958-017-0314-x

 received in 2017-05-22, accepted in 2017-12-03,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundSeveral studies have reported a correlation between antral follicle count by conventional 2D transvaginal sonography and serum anti-Müllerian hormone levels. However, few studies have investigated the effectiveness of 3D SonoAVC transvaginal ultrasound technology, particularly in infertile women. Therefore, this study aims to evaluate the usefulness of three-dimensional (3D) SonoAVC transvaginal ultrasound technology for antral follicle count and its correlation to conventional two-dimensional (2D) transvaginal ultrasound and serum levels of anti-Müllerian hormone in infertile women.MethodsThis cross-sectional study included 42 infertile women with age lower than 40 years that underwent treatment at a private fertility clinic between June and December 2015. Patient data included age, body mass index and cause of infertility. On cycle day 3 the following hormone levels were measured: serum levels of anti-Müllerian hormone, follicle-stimulating hormone, cancer antigen 125, prolactin, thyroid-stimulating hormone and oestradiol; the number of antral follicles was counted as well. The scanning were performed through 2D and 3D technology transvaginal ultrasound.ResultsUsing a Bland-Altman test we demonstrated that both technologies are quite equivalent. However, antral follicle count is higher using 3D ultrasound technology compared to 2D technology (p < 0.001; Wilcoxon test), this finding is mainly remarkable in ovaries with more than 20 antral follicles. Moreover, the mean time required for manual 2D ultrasound and 3D SonoAVC measurements were 275 ± 109 and 103 ± 57 s, respectively (p < 0.001). Serum AMH concentration correlated to the total number of early antral follicles (correlation coefficients = 0.678 and 0.612; p < 0.001 by 2D ultrasound and 3D SonoAVC, respectively; Spearman’s correlation test).ConclusionsAntral follicle count is better estimated using 3D ultrasound compared to 2D technology. A great advantage of 3D SonoAVC was less time required for an examination and the visual advantage when it need to count more than 20 follicles.Trial registrationCAAE: 35141114.4.0000.5327. Registered 10 June 2015.

【 授权许可】

CC BY   
© The Author(s). 2017