Application of intraoperative frozen section examination in the management of female breast cancer in China: a nationwide, multicenter 10-year epidemiological study

World Journal of Surgical Oncology

Research

Bao-Ning Zhang¹  Xiao-Ming Xie²  Ya-Nan Kong²  Lin Zhao³  Wei-Liang Feng⁴  Feng Xu⁵  Qing-Kun Song⁶  Jin-Hu Fan⁶  You-Lin Qiao⁶  Jing Li⁶  Rong Huang⁷  Yu Ren⁸  Ke Wang⁸  Jian-Jun He⁸  Shan Zheng⁹ 

[1] Center of Breast Disease, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 17 South Panjiayuan Lane, 100021, Beijing, P.R. China;Department of Breast Oncology, Sun Yat-Sen University Cancer Center, 651 Dongfeng East, 510060, Guangzhou, P.R. China;Department of Breast Surgery, Liaoning Cancer Hospital, No. 44 Xiaoyanhe Road, Dadong District, 110041, Shenyang, P.R. China;Department of Breast Surgery, Zhejiang Cancer Hospital, No. 38 Banshanqiao Guanji Road, 310022, Hangzhou, P.R. China;Department of Breast-thyroid Surgery, Xiangya Second Hospital, Central South University, No. 139 Renminzhonglu, 410011, Changsha, P.R. China;Department of Cancer Epidemiology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 17 South Panjiayuan Lane, 100021, Beijing, P.R. China;Department of Cancer Epidemiology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 17 South Panjiayuan Lane, 100021, Beijing, P.R. China;Department of Epidemiology, West China School of Public Health, Sichuan University, 610041, Chengdu, Sichuan, P.R. China;Department of Oncosurgery, the First Affiliated Hospital of Medical College, Xi’an Jiaotong Universtiy, 277 Yanta West Road, 710061, Xi’an, P.R. China;Department of Pathology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 17 South Panjiayuan Lane, 100021, Beijing, P.R. China;

关键词: Application mode;    Female breast cancer;    Intraoperative frozen section examination;    Sociodemographic factor;   

DOI  :  10.1186/1477-7819-12-225

 received in 2013-11-16, accepted in 2014-07-04,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundIntraoperative frozen section examination (IFSE) during breast cancer surgery can partly reflect the status of surgical treatment since the surgical method used directly determines the purpose of IFSE use in disease management. This study aims to investigate the application of, changing trends in, and factors influencing IFSE in the management of female breast cancer in China.MethodsWe collected the sociodemographic and clinical data of 4,211 breast cancer patients between 1999 and 2008 and statistically analyzed these data using χ2 or Fisher’s exact tests.ResultsA total of 2,283 (54.22%) patients with breast cancer underwent IFSE. During the 10-year study period, IFSE use was associated with an increase in the number of sentinel lymph node biopsies (SLNB) and breast-conserving surgeries (BS) performed, with significant regional differences noted in this trend (P <0.05). Patients’ education, occupation, age, tumor size estimated by preoperative palpation, and the use of imaging examinations affected the purpose of IFSE use (P <0.05).ConclusionsOur results show that the purpose of IFSE in the surgical treatment of breast cancer in China is gradually approaching that in developed countries. We believe that policymakers must address the differences in breast cancer treatment based on the socioeconomic status of patients. Lastly, the use of IFSE for determining tumor characteristics should be avoided as far as possible, and patient education and breast cancer screening programs tailored to the Chinese population should be established. Our findings may guide the formulation of breast cancer control strategies in China and other low-income countries.

【 授权许可】

Unknown   
© Wang et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.