Effects of 12-week supplementation of Citrus bergamia extracts-based formulation CitriCholess on cholesterol and body weight in older adults with dyslipidemia: a randomized, double-blind, placebo-controlled trial

Lipids in Health and Disease

Research

Jianyu Rao¹  Guoqiang Xing²  Shuxian Zhang³  Tian Shen³  Yong Cai³  Rong Shi⁴ 

[1] Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, 90095, Los Angeles, CA, USA;Department of Radiology & Imaging, Institute of Rehabilitation and Development of Brain Function, The Second Clinical Institute of North Sichuan Medical College, Nanchong Central Hospital, 637000, Nanchong, People’s Republic of China;Lotus Biotech.com LLC, John Hopkins University-MCC, 9601 Medical Center Drive, 20850, Rockville, MD, USA;School of Public Health, Shanghai Jiao Tong University, School of Medicine, 200025, Shanghai, People’s Republic of China;School of Public Health, Shanghai University of T.C.M, 201203, Shanghai, People’s Republic of China;

关键词: Citrus bergamia;    Body mass index;    Blood cholesterol;    Old adults;   

DOI  :  10.1186/s12944-017-0640-1

 received in 2017-10-15, accepted in 2017-12-05,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundsRecent experiments suggest that Citrus bergamia extracts could benefit people with dyslipidemia and obesity but this needs to be further validated.MethodsA total of 98 people age-matched older adults (65 years) with elevated blood lipids were enrolled to receive 12-week supplementation of a Citrus bergamia extracts-based formulation (CitriCholess)(n = 48) and placebo (n = 50).ResultsNo group differences were found in baseline bodyweight, body mass index (BMI), blood cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C) and glucose levels. CitriCholess supplementation resulted in lower levels than placebo in TG (1.83 ± 0.92 vs. 1.95 ± 1.34 mmol/L, P = 0.612), TC (5.14 ± 0.98 vs. 5.44 ± 0.77 mmol/L, P = 0.097), and LDL-C (3.13 ± 0.74 vs. 3.43 ± 0.62 mmol/L, P = 0.032). Compared to placebo, CitriCholess also resulted in greater reductions in body weight (−0.604 ± 0.939 vs. 0.06 ± 0.74 kg, P < 0.01), waist circumferences (−0.60 ± 1.349 cm vs. -0.16 ± 1.503 cm, P < 0.01) and BMI (−0.207 ± 0.357 vs. 0.025 ± 0.274, P < 0.01). Additionally, females had a significantly higher level of HDL-C than males. TC was significantly correlated with LDL-C, and to a less degree, with TG. TG was inversely correlated with HDL-C. Body weight and waist circumference were negatively correlated with HDL-C and positively correlated with glucose.Conclusion12-week supplementation of CitriCholess could benefit lipid metabolism and weight management in old adults with dyslipidemia.

【 授权许可】

CC BY   
© The Author(s). 2017

【 图 表 】

Fig. 1