The effect of miscellaneous oral dosage forms on the environmental pollution of sulfonamides in pig holdings

BMC Veterinary Research

Research Article

Katrin Zessel¹  Jessica Stahl¹  Manfred Kietzmann¹  Jan Henrik Finke²  Christel Charlotte Müller-Goymann²  Jochen Schulz³ 

[1] Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover, Foundation, Buenteweg 17, 30559, Hannover, Germany;Institut Pharmazeutische Technologie, Technische Universität Braunschweig, Mendelssohnstr. 1, 38106, Braunschweig, Germany;Institute for Animal Hygiene, Animal Welfare and Farm Animal Behaviour, Bischofsholer Damm 15, 30173, Hannover, Germany;

关键词: Dust;    Sulfonamides;    Environmental pollution;    Antibiotic residues;    Pigs;   

DOI  :  10.1186/s12917-016-0688-6

 received in 2015-09-14, accepted in 2016-03-18,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundDue to antibiotic treatment of humans and animals, the prevalence of bacterial resistances increases worldwide. Especially in livestock farming, large quantities of faeces contaminated with antibiotics pose a risk of the carryover of the active ingredient to the environment. Accordingly, the aim of the present study was the evaluation of the benefit of different oral dosage forms (powder, pellets, granula) in pigs concerning the environmental pollution of sulfadiazine. Two subtherapeutic dosages were evaluated in powder mixtures to gain information about their potential to pollute the pig barn. Furthermore, a new group of pigs was kept in the stable after powder feeding of another pig group to determine the possible absorption of environmentally distributed antibiotics.Pigs were orally treated with three dosage forms. Simultaneously, sedimentation and airborne dust were collected and plasma and urine levels were determined.ResultsAll formulations result in comparable plasma and urine levels, but massive differences in environmental pollution (powder > pellets, granula). Pigs housing in a contaminated barn exhibit traces of sulfadiazine in plasma and urine.ConclusionUsing pharmaceutical formulations like pellets or granula, the environmental pollution of sulfonamides can significantly be diminished due to massive dust reduction during feeding.

【 授权许可】

CC BY   
© Stahl et al. 2016