Development of the Japanese version of the Pediatric Quality of Life Inventory™ Brain Tumor Module

Health and Quality of Life Outcomes

Research

Akiko Higuchi¹  Iori Sato²  Kiyoko Kamibeppu²  Ryo Nishikawa³  Akitake Mukasa⁴  Nobuhito Saito⁴  Kazuhiko Sugiyama⁵  Yutaka Sawamura⁶  Mizuhiko Terasaki⁷  Kohmei Ida⁸  Yasushi Ishida⁹  Toshihiro Kumabe^1,10  Takaaki Yanagisawa^1,11 

[1] Children's Cancer Association of Japan, 1-3-12 Asakusabashi, 111-0053, Taito-ku, Tokyo, Japan;Department of Family Nursing, Graduate School of Health Sciences and Nursing, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, 113-0033, Bunkyo-ku, Tokyo, Japan;Department of Neuro-Oncology/Neurosurgery, Comprehensive Cancer Center, International Medical Center, Saitama Medical University, 350-1298, 1397-1 Yamane, Hidaka-shi, Saitama, Japan;Department of Neurosurgery, Faculty of Medicine, The University of Tokyo, 113-8655, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan;Department of Neurosurgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan;Department of Neurosurgery, Hokkaido University Hospital, 060-8648, Kita 14, Nishi 5, Kita-ku, Sapporo, Japan;Department of Neurosurgery, Kurume University School of Medicine, 830-0011, Asahimachi 67, Kurume-shi, Fukuoka, Japan;Department of Pediatrics, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, 113-0033, Bunkyo-ku, Tokyo, Japan;Department of Pediatrics, St. Luke's International Hospital, 104-8560, 9-1 Akashi-cho, Chuo-ku, Tokyo, Japan;Departments of Neurosurgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, 980-8574, Aoba-ku, Sendai, Japan;Division of Pediatric Neuro-Oncology, Department of Neuro-Oncology/Neurosurgery, Comprehensive Cancer Center, International Medical Center, Saitama Medical University, 1397-1 Yamane, 350-1298, Hidaka-shi, Saitama, Japan;

关键词: Intraclass Correlation Coefficient;    Japanese Version;    Balance Scale;    Original English Version;    Generic Core Scale;   

DOI  :  10.1186/1477-7525-8-38

 received in 2009-11-04, accepted in 2010-04-14,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundThe Pediatric Quality of Life Inventory™ (PedsQL™) is a widely-used modular instrument for measuring health-related quality of life in children aged 2 to 18 years. The PedsQL™ Brain Tumor Module is comprised of six scales: Cognitive Problems, Pain and Hurt, Movement and Balance, Procedural Anxiety, Nausea, and Worry. In the present study, we developed the Japanese version of the PedsQL™ Brain Tumor Module and investigated its feasibility, reliability, and validity among Japanese children and their parents.MethodsTranslation equivalence and content validity were verified using the standard back-translation method and cognitive debriefing tests. Participants were recruited from 6 hospitals in Japan and the Children's Cancer Association of Japan, and questionnaires were completed by 137 children with brain tumors and 166 parents. Feasibility of the questionnaire was determined based on the amount of time required to complete the form and the percentage of missing values. Internal consistency was assessed using Cronbach's coefficient alpha. Test-retest reliability was assessed by retesting 22 children and 27 parents. Factorial validity was verified by exploratory factor analyses. Known-groups validity was described with regard to whole brain irradiation, developmental impairment, infratentorial tumors, paresis, and concurrent chemotherapy. Convergent and discriminant validity were determined using Generic Core Scales and State-Trait Anxiety Inventory for children.ResultsInternal consistency was relatively high for all scales (Cronbach's coefficient alpha > 0.70) except the Pain and Hurt scale for the child-report, and sufficient test-retest reliability was demonstrated for all scales (intraclass correlation coefficient = 0.45-0.95). Factorial validity was supported through exploratory factor analysis (factor-item correlation = 0.33-0.96 for children, 0.55-1.00 for parents). Evaluation of known-groups validity confirmed that the Cognitive Problems scale was sensitive for developmental impairment, the Movement and Balance scale for infratentorial tumors or paresis, and the Nausea scale for a patient currently undergoing chemotherapy. Convergent and discriminant validity with the PedsQL™ Generic Core Scales and State-Trait Anxiety Inventory for children were acceptable.ConclusionsThe Japanese version of the PedsQL™ Brain Tumor Module is suitable for assessing health-related quality of life in children with brain tumors in clinical trials and research studies.

【 授权许可】

Unknown   
© Sato et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.