The homology of odontodes in gnathostomes: insights from Dlx gene expression in the dogfish, Scyliorhinus canicula

BMC Evolutionary Biology

Research Article

Mélanie Debiais-Thibaud¹  Silvan Oulion²  Didier Casane³  Véronique Borday-Birraux³  Patrick Laurenti³  Franck Bourrat⁴ 

[1] Evolution des familles multigéniques, Laboratoire Evolution Génome et Spéciation, UPR9034 CNRS, 1 avenue de la terrasse, 91198, Gif-sur-Yvette, France;UFR Sciences, Université Paris-Sud 11, 91405, Orsay Cedex, France;Département Forme, Institut des Sciences de l'Evolution - Montpellier, UMR5554 CNRS/Université Montpellier II, Place Eugène Bataillon, 34095, Montpellier, cedex05, France;Evolution des familles multigéniques, Laboratoire Evolution Génome et Spéciation, UPR9034 CNRS, 1 avenue de la terrasse, 91198, Gif-sur-Yvette, France;UFR Sciences, Université Paris-Sud 11, 91405, Orsay Cedex, France;Evolution et développement des chordés, Biologie Intégrative des Organismes Marins, UMR7232 CNRS/UMPC Université Paris 6, Observatoire océanologique, Avenue du Fontaulé, 66650, Banyuls-sur-Mer, France;Evolution des familles multigéniques, Laboratoire Evolution Génome et Spéciation, UPR9034 CNRS, 1 avenue de la terrasse, 91198, Gif-sur-Yvette, France;UFR des Sciences du Vivant, Université Paris Diderot Sorbonne Paris Cité, 5 rue Marie-Andrée Lagroua Weill-Hallé, 75205, Paris Cedex 13, France;Laboratoire Neurobiologie et Développement, Institut de Neurobiologie Alfred Fessard, UPR3294 CNRS, 1 avenue de la terrasse, 91198, Gif-sur-Yvette, France;

关键词: Gene Regulatory Network;    Tooth Development;    Epithelial Compartment;    Early Morphogenesis;    Dermal Denticle;   

DOI  :  10.1186/1471-2148-11-307

 received in 2011-07-11, accepted in 2011-10-18,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundTeeth and tooth-like structures, together named odontodes, are repeated organs thought to share a common evolutionary origin. These structures can be found in gnathostomes at different locations along the body: oral teeth in the jaws, teeth and denticles in the oral-pharyngeal cavity, and dermal denticles on elasmobranch skin. We, and other colleagues, had previously shown that teeth in any location were serially homologous because: i) pharyngeal and oral teeth develop through a common developmental module; and ii) the expression patterns of the Dlx genes during odontogenesis were highly divergent between species but almost identical between oral and pharyngeal dentitions within the same species. Here we examine Dlx gene expression in oral teeth and dermal denticles in order to test the hypothesis of serial homology between these odontodes.ResultsWe present a detailed comparison of the first developing teeth and dermal denticles (caudal primary scales) of the dogfish (Scyliorhinus canicula) and show that both odontodes develop through identical stages that correspond to the common stages of oral and pharyngeal odontogenesis. We identified six Dlx paralogs in the dogfish and found that three showed strong transcription in teeth and dermal denticles (Dlx3, Dlx4 and Dlx5) whereas a weak expression was detected for Dlx1 in dermal denticles and teeth, and for Dlx2 in dermal denticles. Very few differences in Dlx expression patterns could be detected between tooth and dermal denticle development, except for the absence of Dlx2 expression in teeth.ConclusionsTaken together, our histological and expression data strongly suggest that teeth and dermal denticles develop from the same developmental module and under the control of the same set of Dlx genes. Teeth and dermal denticles should therefore be considered as serial homologs developing through the initiation of a common gene regulatory network (GRN) at several body locations. This mechanism of heterotopy supports the 'inside and out' model that has been recently proposed for odontode evolution.

【 授权许可】

Unknown   
© Debiais-Thibaud et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.