Estimation of plasma apolipoprotein B concentration using routinely measured lipid biochemical tests in apparently healthy Asian adults

Cardiovascular Diabetology

Original Investigation

Sookyoung Woo¹  Seonwoo Kim¹  Joon-Hyuk Kong²  Ki-Chul Sung³  Dong-Sik Cho³  Christopher D Byrne⁴ 

[1] Biostatistics Team, Samsung Biomedical Research Institute, Seoul, Republic of Korea;Department of Thoracic and Cardiovascular Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University College of Medicine, Seoul, Korea;Division of Cardiology, Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, #108, Pyung Dong, 110-746, Seoul, Jongro-Ku, Republic of Korea;Nutrition and Metabolism Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, IDS Building, MP 887, Southampton, UK;

关键词: Apolipoprotein;    Formula;    Hypercholesterolemia;    Lipid;    Cholesterol;   

DOI  :  10.1186/1475-2840-11-55

 received in 2012-02-06, accepted in 2012-05-07,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundIncreased low-density lipoprotein cholesterol (LDL) concentration is associated with increased risk of coronary heart disease (CHD) but a substantial risk of cardiovascular disease often remains after LDL concentrations have been treated to target. Apolipoprotein B (apo B) is the major apolipoprotein contained within atherogenic lipoproteins such as LDL, and apo B is a more reliable indicator of cardiovascular risk than LDL concentration.Aim and methodsOur aim was to develop a formula for calculating apo B using lipid biochemistry measurements that are commonly available in clinical practice. We examined the clinical and laboratory data from 73,047 Koreans who underwent a medical health check that included apolipoprotein B concentration. The study sample was randomly divided into a training set for prediction model building and a validation set of equal size. Multivariable linear regression analysis was used to develop a prediction model equation for estimating apo B and to validate the developed model.ResultsThe best results for estimating apo B were derived from an equation utilising LDL and triglyceride (TG) concentrations [ApoB = −33.12 + 0.675*LDL + 11.95*ln(tg)]. This equation predicted the apo B result with a concordance correlation coefficient (CCC and 95%CIs) = 0.936 (0.935,0.937)).ConclusionOur equation for predicting apo B concentrations from routine analytical lipid biochemistry provides a simple method for obtaining precise information about an important cardiovascular risk marker.

【 授权许可】

Unknown   
© Cho et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.