Teaching old drugs new tricks to stop malaria invasion in its tracks

BMC Biology

Commentary

Boris Striepen¹  Vasant Muralidharan¹ 

[1] Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, 30602, Athens, GA, USA;

关键词: Malaria;    Azithromycin;    Artemisinin;    Roxithromycin;    Mass Drug Administration;   

DOI  :  10.1186/s12915-015-0185-6

 received in 2015-09-01, accepted in 2015-09-03,  发布年份 2015

来源: Springer

【 摘 要 】

Malaria is a common and life-threatening disease endemic in large parts of the world. The emergence of antimalarial drug resistance is threatening disease-control measures that depend heavily on treatment of clinical malaria. The intracellular malaria parasite is particularly vulnerable during its brief extracellular stage of the life cycle. Wilson et al. describe a screen targeting these extracellular parasite stages and make the surprising discovery that clinically used macrolide antibiotics are potent inhibitors of parasite invasion into erythrocytes.See research article: http://www.biomedcentral.com/1741-7007/13/52

【 授权许可】

CC BY   
© Muralidharan and Striepen. 2015