Intrathecal magnesium sulfate does not reduce the ED50 of intrathecal hyperbaric bupivacaine for cesarean delivery in healthy parturients: a prospective, double blinded, randomized dose-response trial using the sequential allocation method

BMC Anesthesiology

Research Article

Yinfa Zhang¹  Lizhong Wang¹  Xiaomin Zhang¹  Wenping Xu¹  Ying Feng²  Feng Fu²  Xinzhong Chen²  Fei Xiao³ 

[1] Department of Anesthesia, Jiaxing Maternity and Child Care Hospital, Jiaxing, Zhejiang, China;Department of Anesthesia, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, China;Department of Anesthesia, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, China;Department of Anesthesia, Jiaxing Maternity and Child Care Hospital, Jiaxing, Zhejiang, China;

关键词: Anesthesia;    Spinal;    Magnesium sulfate;    Cesarean delivery;   

DOI  :  10.1186/s12871-017-0300-z

 received in 2016-03-05, accepted in 2017-01-02,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundAddition of intrathecal magnesium sulfate to local anesthetics has been reported to potentiate spinal anesthesia and prolong analgesia in parturients. The current study was to determine whether intrathecal magnesium sulfate would reduce the dose of hyperbaric bupivacaine in spinal anesthesia with bupivacaine and sufentanil for cesarean delivery.MethodsSixty healthy parturients undergoing scheduled cesarean delivery were randomly assigned to receive spinal anesthesia with 0.5% hyperbaric bupivacaine and 5 μg sufentanil with either 0.9% sodium chloride (Control group) or 50% magnesium sulfate (50 mg) (Magnesium group). Effective anesthesia was defined as a bilateral T5 sensory block level achieved within 10 min of intrathecal drug administration and no additional epidural anesthetic was required during surgery. Characteristic of spinal anesthesia and the incidence of side effects were observed. The ED50 for both groups was calculated using the Dixon and Massey formula.ResultsThere was no significant difference in the ED50 of bupivacaine between the Magnesium group and the Control group (4.9 mg vs 4.7 mg) (P = 0.53). The duration of spinal anesthesia (183 min vs 148 min, P < 0.001) was longer, the consumption of fentanyl during the first 24 h postoperatively (343 μg vs 550 μg, P < 0.001) was lower in the Magnesium group than that in the Control group.ConclusionsIntrathecal magnesium sulfate (50 mg) did not reduce the dose requirement of intrathecal bupivacaine, but can extend the duration of spinal anesthesia with no obvious additional side effects.Trial registrationThis study was registered with Chinese Clinical Trial Registry (ChiCTR) on 15 Jul. 2014 and was given a trial ID number ChiCTR-TRC-14004954.

【 授权许可】

CC BY   
© The Author(s). 2017