Hemostatic bioactivity of novel Pollen Typhae Carbonisata-derived carbon quantum dots

Journal of Nanobiotechnology

Research

Huihua Qu¹  Yan Zhao²  Jinjun Cheng²  Xiaoman Liu²  Juan Luo³  Yongzhi Wang³  Xin Yan³  Wei Xiong³  Meiling Zhang³ 

[1] Center of Scientific Experiment, Beijing University of Chinese Medicine, 11 Beisanhuandong Road, Chaoyang District, 100029, Beijing, China;School of Basic Medical Sciences, Beijing University of Chinese Medicine, 100029, Beijing, China;School of Chinese Materia Medica, Beijing University of Chinese Medicine, 100029, Beijing, China;

关键词: Pollen Typhae Carbonisata;    Carbon quantum dots;    Hemostasis;    Charcoal drug;    Drug discovery;   

DOI  :  10.1186/s12951-017-0296-z

 received in 2017-06-08, accepted in 2017-08-29,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundPollen Typhae Carbonisata (PTC) is a type of calcined herb drug that has been used as a hemostatic medicine to promote hemostasis for thousands of years. In this study, we discovered and separated novel water-soluble carbon quantum dots (CQDs, named PTC-CQDs) from aqueous extracts of PTC. These PTC-CDs were characterized using transmission electron microscopy (TEM) and high-resolution TEM, as well as Fourier transform infrared, ultraviolet–visible, and fluorescence spectroscopy. Then, we assessed the anti-hemorrhagic effects and related hemostatic mechanisms of the obtained PTC-CQDs.ResultsThe PTC-CQDs separated from PTC are spherical, monodisperse, and have a narrow size distribution between 2 and 8 nm. In the pharmacology experiment, remarkable anti-hemorrhage effects of PTC-CQDs were revealed. Additionally, the rats showed a profound decrease in activated partial thromboplastin time and increase in fibrinogen and PLT after PTC-CQDs treatment.ConclusionsThese results indicated the explicit hemostasis effect of PTC-CQDs, which not only provided a new idea for the material research of PTC, but have also provided new insights into potential biomedical and healthcare applications of CQDs in the field of haemorrhage control and laid a solid foundation for future drug discovery.

【 授权许可】

CC BY   
© The Author(s) 2017