Protective effect of whey proteins against nonalcoholic fatty liver in rats

Lipids in Health and Disease

Research

Mahmoud Z Sitohy¹  Abdel-Gawad I Abou Dawood²  Essam M Hamad²  Soad H Taha²  Mahmoud Abdel-Hamid² 

[1] Biochemistry Department, Faculty of Agriculture, Zagazig University, Zagazig, Egypt;Dairy Science Department, Faculty of Agriculture, Cairo University, Egypt;

关键词: Fatty Liver;    Whey Protein;    Fatty Infiltration;    Nonalcoholic Fatty Liver Disease;    Whey Protein Isolate;   

DOI  :  10.1186/1476-511X-10-57

 received in 2011-02-09, accepted in 2011-04-13,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundNonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome and can vary from hepatic steatosis to end-stage liver disease. It is the most common liver disease and its prevalence is increasing worldwide. In the present study, the effect of whey proteins on some parameters of NAFLD was investigated.ResultsOral administration of the studied whey proteins products reduced the final body weight of rats. There was a significant reduction effect (P < 0.05) of the tested proteins on hepatic triglycerides, liver enzymes (ALT and AST), lipid peroxidation (malondialdehyde level) and serum glucose. Feeding on whey proteins caused an increase in the reduced glutathione. Hepatic content of reduced glutathione was not affected by any of the used whey proteins, but it showed an increasing tendency (P > 0.05). Liver histology showed an improvement of fatty infiltration in hepatocytes from whey protein groups and gives the histology of liver a normal appearance.ConclusionsThe obtained results indicate a possible role for oral administration of whey proteins in the regulation of liver biochemistries in a rat's model of NAFLD. This regulatory effect of whey proteins was accompanied by an improvement in fatty infiltration in hepatocytes and a reduction of oxidative stress parameters.

【 授权许可】

Unknown   
© Hamad et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.